Serotonin transporter binding in Tourette Syndrome
Serotonin transporter binding in Tourette Syndrome
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DOI：
10.1016/j.neulet.2005.05.031
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发表时间：
2005-09-09
影响因子：
2.5
通讯作者：
Berding, G
中科院分区：
文献类型：
--
作者：
Müller-Vahl, KR;Meyer, GJ;Berding, G
最近的研究提供了证据表明多巴胺能系统参与了抽动秽语综合征（TS）的病理生理学。然而，对其他神经递质系统的可能损害知之甚少。在强迫症（OCD）中，TS的常见合并症，这表明，多巴胺能系统在发病机制中起着重要作用。因此，我们使用[I-123]2[beta]carbomethoxy-3 [beta] -（4-iodophenyl）tropane（[（123）1]beta-CIT）和单光子发射计算机断层扫描（SPECT）研究了12名伴有不同程度强迫行为（OCB）的TS患者和16名年龄匹配的健康对照者的5-羟色胺转运体（SERT）结合能力。TS患者未接受5-羟色胺再摄取抑制剂（SSRI）（n = 8）的结合率显著低于正常对照组（2.8 vs 3.2，p = 0.003）。SSRI治疗导致SERT可用性显著降低。对这一小组进行线性回归分析，无SSRI患者显示SERT上的[I-123] β-CIT结合与OCB（r=-0.78，p =0.023）以及复杂运动性抽搐（r=-0.68，p=0.064）之间呈负相关趋势。在健康对照组中，但不是在TS组中，我们发现SERT结合能力与年龄相关的下降（每年下降0.28%，p = 0.038）。我们的数据与以前的结果一致，表明TS中的多巴胺能系统受损。可以推测，SERT结合能力的降低与共病OCB的程度有关。(c)2005爱思唯尔爱尔兰有限公司保留所有权利。
Recent studies provided evidence for an involvement of the dopaminergic system in the pathophysiology of Tourette Syndrome (TS). However, little is known about possible impairment of other neurotransmitter systems. In obsessive-compulsive disorder (OCD), a common comorbidity in TS, it is suggested that the serotonergic system plays a major role in the pathogenesis. We, therefore, used [I-123]2[beta]carbomethoxy-3 [beta] -(4-iodophenyl)tropane ([(123)1]beta-CIT) and single photon emission computed tomography (SPECT) to investigate serotonin transporter (SERT) binding capacity in 12 patients with TS with various degrees of associated obsessive compulsive behaviour (OCB) and 16 age-matched healthy controls. Binding ratios in TS patients not receiving serotonin reuptake inhibitors (SSRI) (n = 8) were significantly reduced compared to age-adjusted ratios from normal controls (2.8 versus 3.2, p = 0.003). Treatment with SSRI resulted in a significant reduction of SERT availability. Per-forming linear regression analysis for this small group, SSRI-free patients indicated trends for a negative correlation between [I-123]beta-CIT binding on SERT and OCB (r= -0.78, p =0.023) as well as complex motor tics (r= -0.68, p=0.064). In healthy controls, but not in the TS group, we found an age-related decline in SERT binding capacity (0.28% decrease per year, p = 0.038). Our data are in agreement with previous results suggesting an impairment of the serotonergic system in TS. It can be speculated that the reduction in SERT binding capacity is associated with the degree of comorbid OCB. (c) 2005 Elsevier Ireland Ltd. All rights reserved.