Adherent-invasive E. coli in Crohn disease: bacterial "agent provocateur".
Adherent-invasive E. coli in Crohn disease: bacterial "agent provocateur".
复制标题
克罗恩病中的粘附侵袭性大肠杆菌：细菌“挑衅者”。
DOI：
10.1172/jci46333
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Strober,Warren
中科院分区：
文献类型：
--
作者：
Strober,Warren
粘附侵入性E的作用。大肠杆菌（AIEC）与克罗恩病（CD）的关系几十年来一直存在争议。 AIEC 细菌存在于慢性 CD 患者的小肠中，但目前尚不清楚这种感染是否是 CD 患者潜在免疫缺陷的原因或继发因素。在本期 JCI 中，Chassaing 及其同事证明，AIEC 细菌表达一种称为长极菌毛 (LPF) 的粘附因子，有助于这些细菌与派尔氏淋巴结上的 M 细胞结合，并随后进入淋巴组织。这些发现提供了 AIEC 渗透的机制，但并不能证明 AIEC 会引起派尔氏淋巴结原发性感染，而这对于 CD 炎症的发生或持续是必要的。
The role of adherent-invasiveE. coli(AIEC) in Crohn disease (CD) has been in debate for decades. AIEC bacteria are found in the small intestine of patients with chronic CD, but it has remained unclear whether this infection is causal or secondary to underlying immune deficiencies in CD patients. In this issue of theJCI, Chassaing and colleagues demonstrate that AIEC bacteria express an adherence factor called long polar fimbriae (LPF) that aids in the binding of these bacteria to M cells overlying Peyer’s patches and subsequent entry into lymphoid tissue. These findings provide a mechanism of AIEC penetration but do not prove that AIEC is causing a primary infection in the Peyer’s patches that is necessary for the initiation or persistence of CD inflammation.