Andrastins A similar to C, new protein farnesyltransferase inhibitors, produced by Penicillium sp FO-3929
Andrastins A similar to C, new protein farnesyltransferase inhibitors, produced by Penicillium sp FO-3929
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DOI：
10.1016/0040-4039(95)02412-3
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发表时间：
1996-02-19
影响因子：
1.8
通讯作者：
Omura, S
中科院分区：
文献类型：
--
作者：
Shiomi, K;Uchida, R;Omura, S
从青霉FO-3929的培养液中分离出一种新的蛋白质法呢基转移酶抑制剂，andrastins A类似于C（1类似于3）。通过INADEQUATE和C-13-C-13自旋去耦实验，解析了被[1，2-C-13]乙酸酯富集的1的结构。化合物2和3的结构也通过核磁共振实验进行了鉴定。Andrastins具有ent-5 α-14 β-雄甾烷骨架，具有酮-烯醇互变异构现象。
New protein famesyltransferase inhibitors, andrastins A similar to C (1 similar to 3) have been isolated from the cultured broth of Penicillium sp. FO-3929. The structure of 1 enriched by [1,2-C-13]acetate was elucidated by INADEQUATE and C-13-C-13 spin decoupling experiments. The structure of 2 and 3 were also elucidated by NMR experiments. Andrastins had an ent-5 alpha-14 beta-androstane skeleton with keto-enol tautomerism.