Taming influenza viruses.

Taming influenza viruses.
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DOI:
10.1016/j.virusres.2011.09.035
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发表时间:
2011-12
期刊:
影响因子:
5
通讯作者:
Kawaoka, Yoshihiro
Kawaoka, Yoshihiro
中科院分区:
医学3区
文献类型:
--
作者:
Ozawa, Makoto;Kawaoka, Yoshihiro

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以质粒为基础的反向遗传学系统允许用克隆的cDNA源基因组人工产生病毒。自从针对流感病毒建立这样的系统以来,人们已经做出了许多尝试来驯服这种病原体。特别是,已经产生了几种表达外源基因的病毒,并将其用于进一步了解流感病毒的复制和致病性,并开发新的流感疫苗。在这里,我们回顾这些成就,并讨论未来的前景。
Plasmid-based reverse genetics systems allow the artificial generation of viruses with cloned cDNA-derived genomes. Since the establishment of such systems for influenza virus, numerous attempts have been made to tame this pathogenic agent. In particular, several types of viruses expressing foreign genes have been generated and used to further our knowledge of influenza virus replication and pathogenicity and to develop novel influenza vaccines. Here, we review these achievements and discuss future perspectives.
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