Mineralization of the metre-long biosilica structures of glass sponges is templated on hydroxylated collagen
Mineralization of the metre-long biosilica structures of glass sponges is templated on hydroxylated collagen
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DOI：
10.1038/nchem.899
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发表时间：
2010-12-01
期刊：
影响因子：
21.8
通讯作者：
Collins, Matthew J.
中科院分区：
文献类型：
--
作者：
Ehrlich, Hermann;Deutzmann, Rainer;Collins, Matthew J.
参与后生动物骨骼形成的矿物质主要包括玻璃状的二氧化硅、磷酸钙或碳酸钙。由于其古老的遗产，玻璃海绵（Hexactinellida）可能会揭示一些基本问题，如分子进化，第一个骨骼硅基结构的独特化学和形成，以及多细胞动物的起源。我们研究了玻璃绳海绵（Hyalonema sieboldi; Porifera， Hexactinellida类）一米长的茎上的锚定针状物，它们的大小、耐用性、柔韧性和光学性能都非常出色。利用生物二氧化硅的慢碱蚀刻，我们分离出有机部分，发现其主要由羟基化的纤维性胶原蛋白组成，该胶原蛋白含有一个不寻常的[gly - 3hy - 4hyp]基序。我们推测该基序倾向于二氧化硅沉淀，并为自然界的生物硅化提供了一种新的模板。
The minerals involved in the formation of metazoan skeletons principally comprise glassy silica, calcium phosphate or carbonate. Because of their ancient heritage, glass sponges (Hexactinellida) may shed light on fundamental questions such as molecular evolution, the unique chemistry and formation of the first skeletal silica-based structures, and the origin of multicellular animals. We have studied anchoring spicules from the metre-long stalk of the glass rope sponge (Hyalonema sieboldi; Porifera, Class Hexactinellida), which are remarkable for their size, durability, flexibility and optical properties. Using slow-alkali etching of biosilica, we isolated the organic fraction, which was revealed to be dominated by a hydroxylated fibrillar collagen that contains an unusual [Gly-3Hyp-4Hyp] motif. We speculate that this motif is predisposed for silica precipitation, and provides a novel template for biosilicification in nature.