Enhanced antibacterial properties on superhydrophobic micro-nano structured titanium surface
Enhanced antibacterial properties on superhydrophobic micro-nano structured titanium surface
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DOI：
10.1002/jbm.a.37375
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发表时间：
2022-02-21
影响因子：
4.9
通讯作者：
Popat, Ketul C.
中科院分区：
文献类型：
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作者：
Manivasagam, Vignesh K.;Perumal, Gopinath;Popat, Ketul C.
钛基骨科和心血管植入物的微/纳米级表面修饰已证明可以增强生物相容性。然而，细菌感染仍然是种植失败的一个严重问题，抗生素耐药性的增加和抗生素的过度使用会加剧这种情况。植入物表面上的细菌细胞粘附导致定植和生物膜形成，从而导致发病率和死亡率。因此，需要开发具有高抗菌性能的新型植入物表面。最近的发展表明，超疏水表面可防止蛋白质和细菌细胞粘附。在这项研究中，采用热化学处理来改变表面性质，以实现钛表面的高效抗菌活性。这种修饰产生了微纳米表面形貌，并且在用聚乙二醇（PEG）和硅烷修饰后，表面分别具有超亲水性和超疏水性。对改性表面进行了形态、润湿性、化学、耐腐蚀性和表面电荷的表征。通过评估细菌细胞抑制、粘附动力学和生物膜形成来表征金黄色葡萄球菌和大肠杆菌的抗菌能力。结果表明，与未修饰的钛表面相比，孵育24小时后，超疏水微纳结构钛表面显着降低了细菌细胞粘附（>90%）并阻止了生物膜的形成。
Micro/nano scale surface modifications of titanium based orthopedic and cardiovascular implants has shown to augment biocompatibility. However, bacterial infection remains a serious concern for implant failure, aggravated by increasing antibiotic resistance and over usage of antibiotics. Bacteria cell adhesion on implant surface leads to colonization and biofilm formation resulting in morbidity and mortality. Hence, there is a need to develop new implant surfaces with high antibacterial properties. Recent developments have shown that superhydrophobic surfaces prevent protein and bacteria cell adhesion. In this study, a thermochemical treatment was used modify the surface properties for high efficacy antibacterial activity on titanium surface. The modification led to a micro-nano surface topography and upon modification with polyethylene glycol (PEG) and silane the surfaces were superhydrophilic and superhydrophobic, respectively. The modified surfaces were characterized for morphology, wettability, chemistry, corrosion resistance and surface charge. The antibacterial capability was characterized with Staphylococcus aureus and Escherichia coli by evaluating the bacteria cell inhibition, adhesion kinetics, and biofilm formation. The results indicated that the superhydrophobic micro-nano structured titanium surface reduced bacteria cell adhesion significantly (>90%) and prevented biofilm formation compared to the unmodified titanium surface after 24 h of incubation.