Interaction of osmotic and volume stimuli in regulation of neurohypophyseal secretion in rats.
Interaction of osmotic and volume stimuli in regulation of neurohypophyseal secretion in rats.
复制标题
渗透压和容量刺激在大鼠神经垂体分泌调节中的相互作用。
DOI：
10.1152/ajpregu.1986.250.2.r267
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Verbalis,JG
中科院分区：
文献类型：
--
作者：
Stricker,EM;Verbalis,JG
成年雄性大鼠皮下注射聚乙二醇（PEG）溶液，血浆液逐渐等渗浸入局部水肿，导致血容量减少。发现血浆精氨酸加压素 (AVP) 水平在诱导血浆容量不足高达 40% 时呈指数增加。然而，当大鼠自由饮水或灌胃水时，血浆 AVP 降低至基础水平，尽管持续低血容量，血浆渗透压仅稀释 3-6%。高渗氯化钠的施用也刺激了 AVP 的分泌。然而，PEG 和高渗 NaCl 联合治疗产生的血浆 AVP 水平高于根据低血容量和渗透浓度的独立影响的简单相加所预期的水平。催产素的分泌同样受到PEG溶液或高渗氯化钠治疗的刺激，当两种治疗同时进行时，催产素分泌尤其明显，并且尽管血容量明显不足，但它受到渗透稀释的抑制。这些效应类似于低血容量刺激水摄入但随后的渗透稀释抑制 PEG 治疗大鼠口渴时所观察到的效应。
Adult male rats were injected subcutaneously with polyethylene glycol (PEG) solution, which causes hypovolemia by progressive isosmotic leaching of plasma fluid into a local edema. Plasma levels of arginine vasopressin (AVP) were found to increase exponentially in response to induced plasma volume deficits up to 40%. However, plasma AVP was reduced to basal levels when the rats were given either free access to drinking water or intragastric water loads that diluted plasma osmolality by only 3-6% despite continued hypovolemia. Administration of hypertonic NaCl stimulated AVP secretion as well. However, combined PEG and hypertonic NaCl treatments produced plasma AVP levels greater than expected from simple additivity of the independent effects of hypovolemia and osmotic concentration. Oxytocin secretion similarly was stimulated by treatment with either PEG solution or hypertonic NaCl, it was especially pronounced when both treatments were given, and it was inhibited by osmotic dilution despite marked hypovolemia. These effects are analogous to those seen when hypovolemia stimulates water intake but subsequent osmotic dilution inhibits thirst in PEG-treated rats.