Genetic polymorphisms of interleukin-1 beta (IL-1B) and IL-1 receptor antagonist (IL-1RN) and breast cancer risk in Korean women
Genetic polymorphisms of interleukin-1 beta (IL-1B) and IL-1 receptor antagonist (IL-1RN) and breast cancer risk in Korean women
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DOI：
10.1007/s10549-005-9079-6
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发表时间：
2006-03-01
影响因子：
3.8
通讯作者：
Kang, Daehee
中科院分区：
文献类型：
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作者：
Lee, Kyoung-Mu;Park, Sue Kyung;Kang, Daehee
Objective.为了评估白细胞介素-1 β（IL-1B）和IL-1受体拮抗剂（IL-1 RN）基因多态性在乳腺癌发生中的潜在作用，在韩国进行了一项以医院为基础的病例对照研究。1998年9月至2002年1月，从首尔的三家教学医院招募了组织学证实的乳腺癌病例（n = 560）和无癌症史的对照组（n = 509）。采用问卷调查的方法收集乳腺癌危险因素的相关信息。采用PCR-CTPP和PCR方法分别检测IL-1B（-31C/T）和IL-1 RN（内含子2中86 bp可变数目串联重复序列）基因型。采用非条件Logistic回归模型计算校正比值比（OR）和95%可信区间（CI）。IL-1 RN *2等位基因与乳腺癌风险降低相关，具有边缘显著性（OR 0.7，95%CI = 0.48-1.05）。IL-1B CC或TC基因型与乳腺癌风险降低无关（OR = 0.9，95%CI = 0.65-1.16）。而IL-1B C等位基因（CT或CC）与IL-1 RN *2等位基因的联合使用则显著降低乳腺癌的发病风险（OR = 0.6，95% CI = 0.39-0.99）。随着“推定低风险”等位基因数量的增加，观察到风险中度降低趋势（趋势p = 0.07）。BMI和IL-1 RN非 *2等位基因对乳腺癌风险也有提示性的联合作用：BMI和IL-1 RN非 *2等位基因高的女性患乳腺癌的风险是BMI和IL-1 RN *2基因型低的女性的1.7倍。我们的研究结果表明，白细胞介素-1的遗传多态性可能在韩国妇女乳腺癌发展的个体易感性中发挥作用。
Objective. To evaluate the potential role of genetic polymorphisms of interleukin-1 beta (IL-1B) and IL-1 receptor antagonist (IL-1RN) on breast cancer development, a hospital-based case-control study was conducted in Korea.Methods. Histologically confirmed breast cancer cases (n = 560) and controls (n = 509) without cancer history were recruited from three teaching hospitals in Seoul between September 1998 and January 2002. Information on risk factors of breast cancer were collected by interviewed questionnaire. Genotypes of IL-1B (-31C/T) and IL-1RN (86 bp variable number tandom repeats in intron 2) were determined by PCR-CTPP (confronting two-pair primers) and PCR, respectively. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by unconditional logistic regression model.Results. The IL-1RN *2-allele was associated with decreased breast cancer risk with marginal significance (OR 0.7, 95% CI = 0.48-1.05). The IL-1B CC or TC genotype was not associated with decreased risk of breast cancer (OR = 0.9, 95% CI = 0.65-1.16). However, combination of IL-1B C-allele (CT or CC) and IL-1RN *2-allele containing genotypes significantly decreased the risk of breast cancer (OR = 0.6, 95% CI = 0.39-0.99). A moderately decreasing trend of risk was observed as the number of 'putative low risk' allele increased (p for trend = 0.07). Suggestive combined effect on breast cancer risk was also observed between body mass index (BMI) and IL-1RN non-*2 allele: women with higher BMI and IL-1RN non-*2 allele had 1.7-fold higher risk than women with lower BMI and IL-1RN*2 genotypes.Conclusion. Our results suggest that genetic polymorphisms of interleukin-1 may play a role in the individual susceptibility for breast cancer development in Korean women.