Testosterone self-administration in female hamsters.
Testosterone self-administration in female hamsters.
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雌性仓鼠的睾酮自我管理。
DOI：
10.1016/j.bbr.2004.02.010
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Wood,RuthI
中科院分区：
文献类型：
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作者：
Triemstra,JenniferL;Wood,RuthI
滥用合成代谢雄激素类固醇（AAS）是一个日益增长的公共卫生问题。除了它们的合成代谢作用，类固醇也加强了雄性仓鼠的睾酮自我管理。然而，女性使用类固醇的情况落后于男性。雄激素对女性也有益吗？我们确定雌性仓鼠是否自愿通过脑室内（i. c. v.）在操作室中自我给药。12只卵巢完整的雌性仓鼠静脉注射睾酮（1.0μg/μl）19.1±2.3天后，对主动鼻塞（31.5±6.1次/4 h）的偏好显著高于非主动鼻塞（12.5±1.1次/4 h）（P<0.05）。雌性仓鼠的操作行为与先前报道的雄性仓鼠相似。开始自我给药后9.6±2.3天，发情周期变得不规则。停药后13.7±2.6天恢复正常月经周期。为了确定卵巢类固醇对雄激素自我给药的影响，对雌性动物进行卵巢切除术（OVX），并允许其自我给予睾酮10.8±0.5天。之后，更换雌激素，并继续自我给药9.7±0.6天。雌激素对雄激素反应无影响（主动：25.8±6.5次;非主动：8.2±2.0次/4 h，P<0.05）。发情期雌性仓鼠没有表现出显着的偏好刺激男性或女性交配时被封锁，和睾酮自我管理没有改变合作伙伴的偏好。然而，偏好室的活动预测随后的雄激素摄入（R2=0.66，P<0.05）。这些发现与合成代谢类固醇对女性生殖有抑制作用的观点一致。此外，他们认为雄激素奖励的性别差异并不是人类AAS滥用的性别差异的基础（NIH RO 1-DA 12843 RIW）。
Abuse of anabolic-androgenic steroids (AAS) is a growing public health concern. In addition to their anabolic effects, steroids are also reinforcing as demonstrated by testosterone self-administration in male hamsters. However, steroid use in women lags behind that in men. Are androgens also rewarding in females? We determined if female hamsters voluntarily consume testosterone by intracerebroventricular (i.c.v.) self-administration in an operant chamber. Twelve ovary-intact female hamsters self-administering testosterone (1.0μg/μl) i.c.v. for 19.1±2.3 days developed a significant preference (P<0.05) for the active nose-poke (31.5±6.1 nose-pokes/4h) over the inactive nose-poke (12.5±1.1 nose-pokes/4h). Operant behavior in females was similar to that reported previously for male hamsters. Estrous cycles became irregular 9.6±2.3 days after the start of self-administration. Regular cycles resumed 13.7±2.6 days after testosterone was discontinued. To determine the effect of ovarian steroids on androgen self-administration, females were ovariectomized (OVX) and allowed to self-administer testosterone for 10.8±0.5 days. Afterwards, estrogen was replaced, and self-administration continued for an additional 9.7±0.6 days. OVX females maintained their preference for the active (23.9±7.0 nose-pokes/4h) over the inactive nose-poke (12.6±3.4 nose-pokes/4h, P<0.05), and estrogen had no effect on responding for androgen (active: 25.8±6.5 nose-pokes; inactive: 8.2±2.0 nose-pokes/4h, P<0.05). Estrous female hamsters did not show a significant preference for stimulus males or females when mating was blocked, and testosterone self-administration did not alter partner preference. However, activity in the preference chamber predicted subsequent androgen intake (R2=0.66, P<0.05). These findings are consistent with the idea that anabolic steroids have inhibitory effects on female reproduction. Moreover, they suggest that sex differences in androgen reward do not underlie sex differences in AAS abuse in humans (NIH RO1-DA12843 RIW).