Integrated 3D-printed reactionware for chemical synthesis and analysis
Integrated 3D-printed reactionware for chemical synthesis and analysis
复制标题
DOI：
10.1038/nchem.1313
复制
发表时间：
2012-05-01
期刊：
影响因子：
21.8
通讯作者：
Cronin, Leroy
中科院分区：
文献类型：
--
作者：
Symes, Mark D.;Kitson, Philip J.;Cronin, Leroy
三维（3D）打印有可能通过创建定制的低成本设备来改变科学和技术，而这些设备以前需要专用设施来制造。一个有吸引力但尚未开发的应用是使用3D打印机通过将试剂直接打印到3D反应器矩阵中来启动化学反应，从而将反应器的设计，建造和操作置于数字控制之下。在这里，使用低成本的3D打印机和开源设计软件，我们生产了用于有机和无机合成的反应器，其中包括打印的催化剂和其他具有用于电化学和光谱分析的打印组件的架构。这使得反应能够被原位监测，从而可以筛选不同的反应器皿架构对于给定过程的功效，并具有用于设备优化的数字反馈机制。此外，仅通过修改反应件架构，反应结果就可以改变。总之，这种方法构成了一个相对便宜，自动化和可重构的化学发现平台，使化学工程技术进入典型的合成实验室。
Three-dimensional (3D) printing has the potential to transform science and technology by creating bespoke, low-cost appliances that previously required dedicated facilities to make. An attractive, but unexplored, application is to use a 3D printer to initiate chemical reactions by printing the reagents directly into a 3D reactionware matrix, and so put reactionware design, construction and operation under digital control. Here, using a low-cost 3D printer and open-source design software we produced reactionware for organic and inorganic synthesis, which included printed-in catalysts and other architectures with printed-in components for electrochemical and spectroscopic analysis. This enabled reactions to be monitored in situ so that different reactionware architectures could be screened for their efficacy for a given process, with a digital feedback mechanism for device optimization. Furthermore, solely by modifying reactionware architecture, reaction outcomes can be altered. Taken together, this approach constitutes a relatively cheap, automated and reconfigurable chemical discovery platform that makes techniques from chemical engineering accessible to typical synthetic laboratories.