The association of gingivitis and periodontitis with ischemic stroke
The association of gingivitis and periodontitis with ischemic stroke
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DOI：
10.1111/j.1600-051x.2004.00579.x
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发表时间：
2004-05-01
影响因子：
6.7
通讯作者：
Grau, AJ
中科院分区：
文献类型：
--
作者：
Dörfer, CE;Becher, H;Grau, AJ
目的：本研究的目的是评估不同牙周参数与脑缺血的关联。方法：在一项病例对照研究中，303 名连续的缺血性中风或短暂性脑缺血发作患者和 300 名代表性人群对照接受了完整的临床和放射学牙科检查。患者平均在缺血后 3 天接受检查。在每颗牙齿的四个部位测量的个体平均临床附着丧失被用作牙周炎的指示变量。 结果：患者的临床附着丧失比普通人群更高（p6 mm 的牙龈指数 >1.2 的 7.4 倍（95% 置信区间 1.55-15.3），牙龈指数 >1.2 的 18.3 倍（5.84-57.26），放射学骨丢失的风险高出 3.6 倍（1.58-8.28）。结论：牙周炎是脑缺血的独立危险因素，牙周炎症过程的急性加重可能是脑缺血事件的触发因素。
Objectives: The aim of this study was to assess the associations of different periodontal parameters with cerebral ischemia.Methods: In a case-control study, 303 consecutive patients with ischemic stroke or transient ischemic attack, and 300 representative population controls received a complete clinical and radiographic dental examination. Patients were examined on average 3 days after ischemia. The individual mean clinical attachment loss measured at four sites per tooth was used as indicator variable for periodontitis.Results: Patients had higher clinical attachment loss than population (p6 mm had a 7.4 times (95% confidence interval 1.55-15.3) a gingival index >1.2 a 18.3 times (5.84-57.26) and a radiographic bone loss a 3.6 times (1.58-8.28) higher risk of cerebral ischemia than subjects without periodontitis or gingivitis, respectively.Conclusion: Periodontitis is an independent risk factor for cerebral ischemia and acute exacerbation of inflammatory processes in the periodontium might be a trigger for the event of cerebral ischemia.