Short report: Do intestinal nematodes increase the risk for multibacillary leprosy?
Short report: Do intestinal nematodes increase the risk for multibacillary leprosy?
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DOI：
10.4269/ajtmh.2001.65.852
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发表时间：
2001-12-01
影响因子：
3.3
通讯作者：
Ribeiro-Rodrigues, R
中科院分区：
文献类型：
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作者：
Diniz, LM;Zandonade, E;Ribeiro-Rodrigues, R
众所周知，肠道蠕虫会破坏宿主的免疫反应，导致Th2反应，进而可能导致嗜酸性粒细胞增多和与这些寄生虫相关的高免疫球蛋白E滴度。麻风分枝杆菌感染可导致不同的临床和病理形态。多菌型与Th2细胞因子相关，而少菌型与Th1细胞因子相关。我们报告的肠道蠕虫感染在麻风的多菌型患者中显著高于少菌型麻风患者或对照组(优势比为2.99；95%可信区间为1.82-4.95；P=0.006)。分枝杆菌指数和肠道蠕虫的频率之间也发现了直接的相关性。我们的结果表明，肠道蠕虫的存在可能促进麻风支原体感染的建立或进展为更严重的麻风形式。
Intestinal helminths are known to subvert the host's immune response towards a Th2 response, which in turn may lead to both eosinophilia and high immunoglobulin E titers often associated with these parasites. Mycobacterium leprae infection may lead to different clinical and pathological forms. Multibacillary forms are associated with Th2 cytokines, whereas paucibacillary forms are associated with Th1 cytokines. We report a significantly higher frequency of intestinal helminthic infections in patients with the lepromatous form, a multibacillary form of leprosy (odds ratio, 2.99; 95% confidence interval, 1.82-4.95; P = 0.006) when compared with patients with paucibacillary leprosy or to a control group without leprosy. A direct correlation was also found between mycobacterial index and the frequency of intestinal helminths. Our results suggest that the presence of intestinal helminths may facilitate the establishment of M. leprae infection or the progression to more severe forms of leprosy.