Asthma and COPD Are Not Risk Factors for ICU Stay and Death in Case of SARS-CoV2 Infection.
Asthma and COPD Are Not Risk Factors for ICU Stay and Death in Case of SARS-CoV2 Infection.
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DOI：
10.1016/j.jaip.2020.09.044
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Schleich F
中科院分区：
文献类型：
--
作者：
Calmes D;Graff S;Maes N;Frix AN;Thys M;Bonhomme O;Berg J;Debruche M;Gester F;Henket M;Paulus V;Duysinx B;Heinen V;Dang DN;Paulus A;Quaedvlieg V;Vaillant F;Van Cauwenberge H;Malaise M;Gilbert A;Ghuysen A;Gillet P;Moutschen M;Misset B;Sibille A;Guiot J;Corhay JL;Louis R;Schleich F
哮喘患者和慢性阻塞性肺疾病（COPD）患者的病毒感染结果比无阻塞性疾病的人更严重。评估阻塞性疾病是否是2019冠状病毒病（COVID 19）导致重症监护室（ICU）住院和死亡的风险因素。我们收集了2020年3月18日至4月17日期间在列日大学医院住院的596名成人患者的电子病历数据，用于严重急性呼吸综合征冠状病毒2（SARS-CoV 2）感染。我们根据COVID 19大流行之前存在的基础呼吸系统疾病将患者分为3组。在因COVID 19需要住院的患者中，哮喘和COPD分别占9.6%和7.7%。在ICU住院的哮喘患者、COPD患者和非阻塞性气道疾病患者的比例分别为17.5%、19.6%和14%。三分之一的COPD患者在住院期间死亡，而只有7.0%的哮喘患者和13.6%的无气道阻塞患者死于SARS-CoV 2。多因素分析显示，哮喘、COPD、吸入糖皮质激素治疗和口服糖皮质激素治疗不是ICU住院或死亡的独立危险因素。男性性别（比值比[OR]：1.9; 95%置信区间[CI]：1.1-3.2）和肥胖（OR：8.5; 95%CI：5.1-14.1）是ICU入院的预测因素，而男性（OR 1.9; 95% CI：1.1-3.2）、高龄（OR：1.9; 95% CI：1.6-2.3）、心脏病（OR：1.8; 95% CI：1.1-3.1）和免疫抑制性疾病（OR：3.6; 95% CI：1.5-8.4）是死亡的独立预测因素。哮喘和COPD不是SARS-CoV 2感染相关ICU入院和死亡的危险因素。
Asthmatics and patients with chronic obstructive pulmonary disease (COPD) have more severe outcomes with viral infections than people without obstructive disease. To evaluate if obstructive diseases are risk factors for intensive care unit (ICU) stay and death due to coronavirus disease 2019 (COVID19). We collected data from the electronic medical record from 596 adult patients hospitalized in University Hospital of Liege between March 18 and April 17, 2020, for severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection. We classified patients into 3 groups according to the underlying respiratory disease, present before the COVID19 pandemic. Among patients requiring hospitalization for COVID19, asthma and COPD accounted for 9.6% and 7.7%, respectively. The proportions of asthmatics, patients with COPD, and patients without obstructive airway disease hospitalized in the ICU were 17.5%, 19.6%, and 14%, respectively. One-third of patients with COPD died during hospitalization, whereas only 7.0% of asthmatics and 13.6% of patients without airway obstruction died due to SARS-CoV2. The multivariate analysis showed that asthma, COPD, inhaled corticosteroid treatment, and oral corticosteroid treatment were not independent risk factors for ICU admission or death. Male gender (odds ratio [OR]: 1.9; 95% confidence interval [CI]: 1.1-3.2) and obesity (OR: 8.5; 95% CI: 5.1-14.1) were predictors of ICU admission, whereas male gender (OR 1.9; 95% CI: 1.1-3.2), older age (OR: 1.9; 95% CI: 1.6-2.3), cardiopathy (OR: 1.8; 95% CI: 1.1-3.1), and immunosuppressive diseases (OR: 3.6; 95% CI: 1.5-8.4) were independent predictors of death. Asthma and COPD are not risk factors for ICU admission and death related to SARS-CoV2 infection.
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