A re-evaluation of the use of rink, BAL, and PAL resins and linkers
A re-evaluation of the use of rink, BAL, and PAL resins and linkers
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重新评估 rink、BAL 和 PAL 树脂和连接剂的使用
DOI：
10.1002/qsar.200420013
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
F. Albericio
中科院分区：
文献类型：
--
作者：
Francesc Yraola;R. Ventura;M. Vendrell;A. Colombo;Joan;N. D. L. Figuera;D. Fernández;M. Royo;A. P. Forns;F. Albericio
The preparation of amine and guanidine derivatives of phenylalaninamide and tryptophanamide as well as benzylamines from BAL, Rink-MBHA, and Rink resins has been performed. Cleavage of the target compound gave significant amounts of byproducts compounds in which the linker moiety was attached to the target unit. This side reaction can be avoided when the solid supports are prepared by anchoring the corresponding linker to an aminomethyl resin.
