Lignans from the Fruits of Forsythia suspensa (Thunb.) Vahl Protect High-Density Lipoprotein during Oxidative Stress
Lignans from the Fruits of Forsythia suspensa (Thunb.) Vahl Protect High-Density Lipoprotein during Oxidative Stress
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DOI：
10.1271/bbb.80392
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发表时间：
2008-10-01
影响因子：
1.6
通讯作者：
Bae, KiHwan
中科院分区：
文献类型：
--
作者：
Chang, Min-Jung;Hung, Tran Manh;Bae, KiHwan
本研究的目的是研究从连翘果实中提取的木脂素类化合物的有益性质。Vahl（Oleaccae）用于保护人高密度脂蛋白（HDL）免受脂质过氧化。分离的化合物（1 - 8）以剂量依赖性方式抑制硫代巴比妥酸反应性物质（TBARS）的产生，IC 50值为8.5 - 18.7 μ M，因为HDL氧化由催化性Cu 2+介导。它们还对热不稳定自由基引发剂（AAPH）诱导的HIM脂质过氧化产生抑制作用，IC 50值为12.1至51.1 μ M。化合物1和5对Cu 2 +-诱导的HDL脂质过氧化有抑制作用，如在3.0 μ M浓度下延长的滞后时间所示。这些结果表明，F。悬浮物是由于其木脂素，这些成分可能是有用的，防止氧化的HDL。
The objective of the present study was to investigate the beneficial properties lignan compounds obtained from the fruits of Forsythia suspensa (Thunb.) Vahl (Oleaccae) for protecting human high-density lipoprotein (HDL) against lipid peroxidation. The isolated compounds (1-8) inhibited the generation of thiobarbituric acid-reactive substances (TBARS) in a dose-dependent manner with IC50 values from 8.5 to 18.7 mu M, since HDL oxidation mediated by catalytic Cu2+. They also exerted an inhibitory effect against thermo-labile radical initiator (AAPH)-induced lipid peroxidation of HIM, with IC50 values from 12.1 to 51.1 mu M. Compounds 1 and 5 exerted inhibitory effects against the Cu2+-induced lipid peroxidation of HDL, as shown by an extended lag time prolongation at the concentration of 3.0 mu M. These results suggest that the antioxidative effects of F. suspensa are due to its lignans and that these constituents may be useful for preventing the oxidation of HDL.