Postradiation sarcomas: 20 cases and a literature review
Postradiation sarcomas: 20 cases and a literature review
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DOI：
10.1016/s0360-3016(99)00279-5
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发表时间：
1999-11-01
影响因子：
7
通讯作者：
Taylor, DA
中科院分区：
文献类型：
--
作者：
Murray, EM;Werner, D;Taylor, DA
用途：分析20例放射后肉瘤（PRS），以确定剂量水平，这种情况下发展，病理的初始和放射后肿瘤，潜伏期，和结果，并回顾文献，并提出修改后的诊断标准。重建既往照射野和等剂量图，以确定随后发生PRS的组织中接受的剂量。结果：有16例女性患者和4例男性患者。初次放疗时的平均年龄为28岁。平均潜伏期为14年，成人组和儿童组之间的潜伏期没有差异（t = 0.45，p = 0.37），但视网膜母细胞瘤患者的潜伏期短于非视网膜母细胞瘤患者（t = 3.18，p = 0.003），预后差; 18例因PRS死亡的患者中位生存期为1年。必须避免不必要的辐射。应详细报告病例，以便确定风险因素。PRS通常出现在中等至较高剂量区域，诊断标准应允许软组织肿瘤和短潜伏期。(C)1999 Elsevier Science Inc.
Purpose: To analyze 20 cases of postradiation sarcoma (PRS) to determine dose levels at which this condition developed, the pathology of the initial and postradiation tumors, latency period, and outcome; and to review the literature and propose modified criteria for diagnosis.Methods and Materials: Patient records were reviewed. Previous radiation fields and isodose charts were reconstructed to determine the dose received in the tissue in which the PRS subsequently developed,Results: There were 16 female patients and 4 male patients. Mean age at the time of initial radiotherapy was 28 years. Mean latency was 14 years, with no difference in latency between the adult and pediatric group (t = 0.45, p = 0.37), but shorter latency in the retinoblastoma than in the nonretinoblastoma patients (t = 3.18,p = 0.003), The outcome was poor; 2 patients were alive and disease-free at 2 and 5 years, The 18 patients who died as a result of PRS had a median survival of 1 year.Conclusion: PRSs are rare. Unnecessary radiation must be avoided. Cases should be reported with full details so that risk factors can be ascertained. PRSs usually arise in moderate to higher dose areas, Diagnostic criteria should allow soft tissue tumors and short latency. (C) 1999 Elsevier Science Inc.