CD154 and type-1 cytokine response: from hyper IgM syndrome to human immunodeficiency virus infection.
CD154 and type-1 cytokine response: from hyper IgM syndrome to human immunodeficiency virus infection.
复制标题
CD154 和 1 型细胞因子反应：从高 IgM 综合征到人类免疫缺陷病毒感染。
DOI：
10.1086/338003
复制
发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Subauste,CarlosS
中科院分区：
文献类型：
--
作者：
Subauste,CarlosS
CD 40和CD 154（CD 40配体）是T细胞和抗原呈递细胞之间相互作用的核心表面分子。本文综述了CD 40-CD 154相互作用在调节弓形虫（Toxoplasma gondias，一种细胞内病原体）介导的IL-12/IFN-γ产生中的作用。CD 154信号传导缺陷的方式有助于免疫抑制和易感性的机会性感染的患者与X-连锁高IgM综合征和人类免疫缺陷病毒感染的患者进行了讨论。
CD40 and CD154 (CD40 ligand) are surface molecules that are central to the cross-talk between T cells and antigen-presenting cells. This article reviews the relevance of CD40-CD154 interaction for regulation of interleukin-12/interferon-γ production in response toToxoplasma gondiias an example of an intracellular pathogen. The manner in which defects in CD154 signaling contribute to immunosuppression and susceptibility to opportunistic infections in patients with X-linked hyper IgM syndrome and in patients with human immunodeficiency virus infection is also discussed.