Incidence of HIV-1 dual infection and its association with increased viral load set point in a cohort of HIV-1 subtype C-infected female sex workers
Incidence of HIV-1 dual infection and its association with increased viral load set point in a cohort of HIV-1 subtype C-infected female sex workers
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DOI：
10.1086/423940
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发表时间：
2004-10-01
影响因子：
6.4
通讯作者：
Williamson, C
中科院分区：
文献类型：
--
作者：
Grobler, J;Gray, CM;Williamson, C
本纵向研究旨在确定女性性工作者队列中双重人类免疫缺陷病毒1型（HIV-1）感染的发病率和致病意义。通过使用异双工迁移性测定和测序对31名新近感染妇女的血液样本进行筛选。中位病毒载量设定点为5404拷贝/mL (n=22)，采用bDNA测定法测定。在感染后3个月内，19%（6/31）的妇女双重感染2种不同的HIV-1亚型C病毒。在24个月的随访过程中未发现重复感染的证据，表明双重感染的风险在初次感染时最高。双重感染与病毒载量设定点升高之间存在显著关联。
This longitudinal study aimed to determine the incidence and pathogenic implications of dual human immunodeficiency virus type 1 (HIV-1) infection in a cohort of female sex workers. Blood samples from 31 recently infected women were screened by use of a heteroduplex mobility assay and sequencing. The median viral load set point was 5404 copies/mL (n=22), which was measured by use of the bDNA assay. Within 3 months of infection, 19% (6/31) of the women were dually infected with 2 distinct HIV-1 subtype C viruses. No evidence of superinfection was detected over the course of 24 months of follow-up, indicating that the risk of dual infection is highest around the time of the initial infection. There was a significant association between dual infection and elevated viral load set point.