Dynamics of pneumococcal carriage among day-care center attendees during the transition from the 7-valent to the higher-valent pneumococcal conjugate vaccines in Greece
Dynamics of pneumococcal carriage among day-care center attendees during the transition from the 7-valent to the higher-valent pneumococcal conjugate vaccines in Greece
复制标题
DOI：
10.1016/j.vaccine.2014.09.016
复制
发表时间：
2014-11-12
期刊：
影响因子：
5.5
通讯作者：
Syrogiannopoulos, George A.
中科院分区：
文献类型：
--
作者：
Grivea, Ioanna N.;Priftis, Kostas N.;Syrogiannopoulos, George A.
工作背景：在希腊，高效价肺炎球菌结合疫苗（PCV）取代了7价（PCV 7），10价（PCV 10）和13价（PCV 13）分别于2009年5月和2010年6月上市。方法：调查雅典和维奥蒂亚地区日托中心参加者鼻咽部肺炎链球菌定植情况。2010年12月至2011年6月，鼻咽培养获得4次，在登记，然后每6至8 weeks.Results：在233名儿童中，225（96.6%）已接种≥ 1剂PCV 7。十分之一的接种PCV 7疫苗的参与者还接受了>= 1剂PCV 13或PCV 10。在4次采样期间，从总共874个样品中回收了358个分离株。233名儿童中检出183名（78.5%）S.肺炎至少一次。携带者之间的总体血清型分布相似，不考虑自末次PCV 7给药后经过的时间。19 A的高频率（17.1%）与19 F的低频率（1.4%）相一致。非PCV 13血清型占分离株的73.1%，其中23 B、15 B/C、16 F、21、11 A、15 A、6C、10A、22 F和23 A最为常见。在24-59个月（中位年龄42个月）的参与者中，非PCV 13血清型的长期携带相对常见，主要是21和16 F。一个4例定植与流行的非PCV 13血清型，随后持续携带5至14 weeks.Conclusions：在此期间的过渡到更高价的PCV在日托中心设置，非PCV 13血清型占主导地位，并表现出长期的殖民化。如果增加采样频率并考虑阳性培养前后的携带时间，则延长携带的频率和持续时间趋于增加。关于定殖的非PCV 13血清型的适合性的进一步研究将在未来可能看到。(C)2014爱思唯尔有限公司版权所有。
Background: In Greece recently, higher-valent pneumococcal conjugate vaccines (PCVs) replaced the 7-valent (PCV7); the 10-valent (PCV10) became available in May 2009 and the 13-valent (PCV13) in June 2010.Methods: We investigated the nasopharyngeal colonization with Streptococcus pneumoniae in day-care center attendees in Athens and the prefecture of Viotia. Between December 2010 and June 2011, nasopharyngeal cultures were obtained 4 times, at enrollment and then every 6 to 8 weeks.Results: Among the 233 children, 225 (96.6%) had been vaccinated with >= 1 dose of PCV7. One tenth of the PCV7 vaccinated attendees had also received >= 1 dose of PCV13 or PCV10. During the 4 samplings, 358 isolates were recovered from a total of 874 samples. Of the 233 children, 183 (78.5%) were found to carry S. pneumoniae at least once. The overall serotype distribution among carriers was similar regardless of the time lapsed since the last PCV7 dose. A high frequency of 19A (17.1%) coincided with a low frequency of 19F (1.4%). Non-PCV13 serotypes accounted for 73.1% of the isolates; 23B, 15B/C, 16F, 21, 11A, 15A, 6C, 10A, 22F and 23A were the most common. Among attendees aged 24-59 months (median age 42 months), prolonged carriage of a non-PCV13 serotype was relatively common, mainly for 21 and 16F. One out of 4 cases of colonization with the prevalent non-PCV13 serotypes was followed by persistent carriage for 5 to 14 weeks.Conclusions: During this period of transition to the higher-valent PCVs in the day-care center setting, non-PCV13 serotypes dominated and exhibited prolonged colonization. The frequency and the duration of prolonged carriage tends to be increased, if sampling frequency increases and the carriage time before and after positive cultures is taken into consideration. Further studies regarding the fitness of the colonizing non-PCV13 serotypes will likely to be seen in the future. (C) 2014 Elsevier Ltd. All rights reserved.