Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload
Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload
复制标题
DOI：
10.1053/euhj.2001.2822
复制
发表时间：
2001-12-01
影响因子：
39.3
通讯作者：
Pennell, DJ
中科院分区：
文献类型：
--
作者：
Anderson, LJ;Holden, S;Pennell, DJ
目的开发和验证一种非侵入性的方法测量心肌铁，以允许诊断和治疗前明显的心肌病和失败development.Methods和结果我们已经开发出一种新的磁共振T2-星星（T2*）技术测量组织铁，与验证化学估计铁在接受肝活检的患者。为了评估这项技术的临床价值，我们随后在106例重型地中海贫血患者中将通过这种T2* 技术测量的心肌铁与心室功能相关联。肝活检铁浓度与肝T2* 呈显著的曲线负相关（r=0（.）93，P
Aims To develop and validate a non-invasive method for measuring myocardial iron in order to allow diagnosis and treatment before overt cardiomyopathy and failure develops.Methods and Results We have developed a new magnetic resonance T2-star (T2*) technique for the measurement of tissue iron, with validation to chemical estimation of iron in patients undergoing liver biopsy. To assess the clinical value of this technique, we subsequently correlated myocardial iron measured by this T2* technique with ventricular function in 106 patients with thalassaemia major. There was a significant, curvilinear, inverse correlation between iron concentration by biopsy and liver T2* (r=0(.)93, P