The effect of oral contraceptives on uterine contractility and menstrual pain: an assessment with cine MR imaging
The effect of oral contraceptives on uterine contractility and menstrual pain: an assessment with cine MR imaging
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DOI：
10.1093/humrep/dem122
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发表时间：
2007-07-01
影响因子：
6.1
通讯作者：
Fujii, Shingo
中科院分区：
文献类型：
--
作者：
Kido, Aki;Togashi, Kaori;Fujii, Shingo
背景：低剂量口服避孕药（OC）已被报道控制原发性痛经。此外，痛经和子宫收缩之间的密切关系已被可视化与磁共振成像（MRI）。本研究旨在使用电影MR来证明OC对月经期间子宫肌层收缩力的影响，并将这些发现与痛经联系起来。方法：对21名服用OC的健康女性志愿者（22-47岁）和20名未服用OC的对照女性（24-39岁）进行MR检查。在月经期间使用1.5T磁体获得电影和静态MR图像。通过电影MR上子宫内膜扭曲的存在、子宫肌层中矢状面的面积和静态图像上子宫内膜下低信号区的厚度来评估子宫收缩力。通过问卷调查评估痛经。结果：共有21名OC使用者和20名对照者被纳入分析。OC组的子宫内膜变形明显不明显，子宫内膜下低信号区明显变薄。此外，在OC组中，子宫肌层面积更大（尽管不显著），并且评估的疼痛程度显著更低。结论：电影和静态MR图像均表明，OC使用者的子宫肌层收缩力相对受到抑制，这可能是解释OC使用者月经疼痛减少的原因之一。
BACKGROUND: Low-dose oral contraceptives (OC) have been reported to control primary dysmenorrhea. Furthermore, a close relationship between dysmenorrhea and uterine contractions has been visualized with magnetic resonance imaging (MRI). This study aimed to use cine MR to demonstrate the effects of OC on myometrial contractility during menstruation and to associate the findings with dysmenorrhea. METHODS: MR studies were obtained of 21 healthy female volunteers (22-47 years old) taking OC, and 20 control women (24-39 years old) not taking OC. Cine- and static MR images were obtained with a 1.5 T magnet during menstruation. Uterine contractility was assessed by the presence of endometrial distortion on cine MR, the area of the mid-sagittal uterine myometrium, and the thickness of the subendometrial low-intensity area on static images. Dysmenorrhea were assessed via a questionnaire. RESULTS: A total of 21 OC users and 20 controls were included in the analysis. Endometrial distortion was significantly less prominent and the subendometrial low-intensity area was significantly thinner in the OC group. Furthermore in the OC group, the uterine myometrial area was larger (although not significantly) and the degree of assessed pain was significantly lower. CONCLUSIONS: Both cine- and static MR images demonstrate that myometrial contractility was relatively suppressed in OC users, which may represent one of the reasons explaining the reduced menstrual pain experienced by OC users.