Cumulative flying time and risk of venous thromboembolism
Cumulative flying time and risk of venous thromboembolism
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DOI：
10.1111/j.1365-2141.2011.08899.x
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发表时间：
2011-12-01
影响因子：
6.5
通讯作者：
Whyte, Ken
中科院分区：
文献类型：
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作者：
MacCallum, Peter K.;Ashby, Deborah;Whyte, Ken
与累积飞行时间相关的静脉血栓栓塞 (VTE) 风险仍不确定。在英国全科诊所开展的一项病例对照研究中，参与者包括从执业记录和 1971 年年龄和性别匹配的对照中确定的 550 例 VTE 病例。参与者返回了相同的调查问卷，询问包括航空旅行详细信息在内的信息。与不乘坐飞机相比，过去 4 周内累计飞行时间 > 12 小时与 VTE 风险增加三倍相关 [比值比 (OR) 2.75，95% 置信区间 (CI)，1.44-5.28]。过去 4 周单腿飞行超过 4 小时的人发生 VTE 的风险是其两倍（OR 2.20，95% CI，1.29-3.73）。这些风险在 12 周时不再明显，并且与日间手术或小型手术的风险相似（OR 5.35，95% CI，2.15-13.33）。中危和高危手术的等效风险分别超过30倍（OR 36.57，95% CI，13.05-102.52）和140倍（OR 141.71，95% CI，19.38-1036.01）。累积和长途航空旅行与 VTE 关联的暂时性表明存在因果关系。对于那些因手术、既往静脉血栓栓塞或肥胖而基线风险较高的人，乘坐飞机旅行会进一步增加静脉血栓栓塞的风险。
The risk of venous thromboembolism (VTE) associated with cumulative flying time remains uncertain. In a case-control study in general practices throughout the UK, participants comprised 550 VTE cases identified from practice records and 1971 age- and gender-matched controls. Participants returned identical questionnaires asking for information including air travel details. Compared to not flying, cumulative flying time >12 h within the previous 4 weeks was associated with a threefold increase in the risk of VTE [odds ratio (OR) 2.75, 95% confidence interval (CI), 1.44-5.28]. Those who had flown >4 h in a single leg in the previous 4 weeks had twice the risk of VTE (OR 2.20, 95% CI, 1.29-3.73). These risks were no longer evident by 12 weeks and were similar to those of day-case or minor surgery (OR 5.35, 95% CI, 2.15-13.33). Equivalent risks for moderate and high-risk surgery were over 30-fold (OR 36.57, 95% CI, 13.05-102.52) and 140-fold (OR 141.71, 95% CI, 19.38-1036.01) respectively. The temporary nature of the association of cumulative and long-haul air travel with VTE suggests a causal relationship. The risks of VTE in those with a higher baseline risk due to surgery, previous VTE or obesity are further increased by air travel.