Cancer risk in association with Parkinson disease: A population-based study
Cancer risk in association with Parkinson disease: A population-based study
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DOI：
10.1016/j.parkreldis.2009.11.005
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发表时间：
2010-03-01
影响因子：
4.1
通讯作者：
Meier, Christoph R.
中科院分区：
文献类型：
--
作者：
Becker, Claudia;Brobert, Gunnar P.;Meier, Christoph R.
研究目的：帕金森病（PD）与癌症风险之间关系的大规模人群研究数据很少。我们比较了有或没有PD患者发生癌症的风险。方法我们进行了一项基于人群的随访研究和一项巢式病例对照分析，数据来自英国全科医学研究数据库。我们纳入了1994年至2005年首次诊断为PD的年龄≥ 40岁的PD患者，我们评估了癌症发病率和相对风险估计，（比值比[OR]和95%置信区间[CI]）结果与非PD患者相比，PD患者发生癌症的风险总体上较低（粗发病率比0.77，95% CI 0.64-0.92）巢式病例对照分析中（所有癌症的adjOR为0.72，95%CI为0.59 ~ 0.87）吸烟相关癌症的风险降低最强（adjOR 0 47，95% CI 0 31-0 72）由于患者数量少，血液系统恶性肿瘤的校正OR为0 32（95% CI 0 14 ~ 0 74）。其他癌症实体的OR未达到统计学显著性。在这项大型观察性研究中，PD患者患癌症的可能性低于未患PD的个体（C）2009 Elsevier Ltd版权所有
Purpose Data from large population-based studies on the association between Parkinson disease (PD) and the risk of developing cancer are scarce. We compared the risk of developing incident cancer between patients with or without PDMethods We conducted a population-based follow-up study and a nested case-control analysis using data from the UK-based General Practice Research Database We included PD patients aged >= 40 years with a first PD diagnosis between 1994 and 2005, and a matched comparison group free of PD We assessed cancer incidence rates and relative risk estimates (odds ratios [ORs] with 95% confidence intervals [CI])Results The risk of developing cancer overall was lower in PD patients as compared to patients without PD (crude incidence rate ratio 077, 95% CI 0.64-0.92) In the nested case-control analysis (adj OR for all cancers 0 72, 95% CI 0 59-0 87) the risk reduction was strongest for smoking-related cancers (adj OR 0 47, 95% CI 0 31-0 72) The adjusted OR for hematological malignancies was 032 (95% CI 0.14-0 74) Due to small numbers. ORs for other cancer entities did not reach statistical significanceConclusions With the exception of melanoma. PD patients were less likely to develop cancer than individuals without PD in this large observational study (C) 2009 Elsevier Ltd All rights reserved