Carbon Nanotubes in Biomedical Applications: Factors, Mechanisms, and Remedies of Toxicity
Carbon Nanotubes in Biomedical Applications: Factors, Mechanisms, and Remedies of Toxicity
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DOI：
10.1021/acs.jmedchem.5b01770
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发表时间：
2016-09-22
影响因子：
7.3
通讯作者：
Memic, Adnan
中科院分区：
文献类型：
--
作者：
Alshehri, Reem;Ilyas, Asad Muhammad;Memic, Adnan
碳纳米管是碳的同素异形体中研究最多的一类。碳纳米管独特的物理化学性质使其成为生物医学领域众多应用的主要候选者，包括药物输送，基因治疗，生物传感器和组织工程应用。然而，CNT的毒性一直是其在生物医学应用中的主要关注点。在这篇综述中，我们提出了碳纳米管在生物医学应用的概述，我们特别关注影响其毒性的各种因素和机制。我们已经讨论了各种参数，包括尺寸，长度，团聚，和杂质的碳纳米管，可能会导致氧化应激，这往往是碳纳米管的毒性的主要机制。其他有毒途径也进行了检查，并讨论了克服这些挑战的可能方法。
Carbon nanotubes (CNTs) represent one of the most studied allotropes of carbon. The unique physicochemical properties of CNTs make them among prime candidates for numerous applications in biomedical fields including drug delivery, gene therapy, biosensors, and tissue engineering applications. However, toxicity of CNTs has been a major concern for their use in biomedical applications. In this review, we present an overview of carbon nanotubes in biomedical applications; we particularly focus on various factors and mechanisms affecting their toxicity. We have discussed various parameters including the size, length, agglomeration, and impurities of CNTs that may cause oxidative stress, which is often the main mechanism of CNTs' toxicity. Other toxic pathways are also examined, and possible ways to overcome these challenges have been discussed.