CENTRAL NERVOUS SYSTEM INVOLVEMENT DURING MUMPS
CENTRAL NERVOUS SYSTEM INVOLVEMENT DURING MUMPS
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DOI：
10.1097/00000441-194804000-00012
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发表时间：
1948-01-01
影响因子：
3.1
通讯作者：
HEIN, GE
中科院分区：
文献类型：
--
作者：
BROWN, JW;KIRKLAND, HB;HEIN, GE
Clinical observations and cerebrospinal fluidexaminations were made on 77 consecutive cases of jnumps encountered in a U.S. Army hospital in England during 1942-44. Pleocytosis was found in 26 instances (33-7 per cent.). Nine of the 77 patients had symptoms suggestive of meningoencephahtis and 8 of these showed pleocytosis in the spinal fluid. The other 68 patients had no clinical evidence of meningo-encephalitis, but 18 (26-4 per cent.) showed increased spinal fluid cell counts. Pleocytosis in the spinal fluid was found more frequently in patients developing epididymo-orchitis, 8 (42-1 per cent.) of 19 cases. There was no correlation between the number of cells and clinical evidence of central nervous system involvement. The case history of one patient suffering from acute meningoencephalitis during the course of bilateral acute epididymo-orchitis, probably due to mumps, is presented in some detail because of the likelihood that mumps was the cause of serious central nervous system damage which resulted, and which has persisted with slight tendency to improvement for at least 31/2 years. From their studies the authors believe that it seems reasonable that every patient with mumps is subject to the neurotropic effects of this virus. They suggest that invasion of the central nervous system, without clinical evidence of involvement of this system, may be a regular feature of many infections, citing in proof of this their experience on lumbar puncture of 6 consecutive adult patients with measles. The cerebrospinal fluid cell counts were as follows: 26, 14, 11, 2, 1 and 0 per cmm. The patient with the highest cell count suffered from nausea, 'vomiting, slight confusion, and mild stiff neck. None of the others gave evidence of central nervous system involvement.A. Joe.
