Genome evolution in yeasts
Genome evolution in yeasts
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DOI：
10.1038/nature02579
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发表时间：
2004-07-01
期刊：
影响因子：
64.8
通讯作者：
Souciet, JL
中科院分区：
文献类型：
--
作者：
Dujon, B;Sherman, D;Souciet, JL
通过比较基因组学确定真核基因组进化的机制通常会因在单个谱系的整个史上发生的多种事件而变得复杂，仅在每个生物体的基因组中留下扭曲和叠加的痕迹。 Hemiascomycete酵母具有紧凑的基因组，相似的生活方式以及独特的性和生理特性，为探索这种机制提供了独特的机会。我们在这里介绍了四种酵母菌物种的完整组装基因组序列，这些基因组序列被选为单个真核门内的广泛进化范围，在分析后，该酵母菌序列与整个弦核状况一样多样化。总共确定了大约24,200个新型基因，其翻译产物与酿酒酵母蛋白一起分为大约4,700个家族，为种间比较构成了基础。染色体图和基因组冗余的分析表明，不同的酵母菌谱系通过几种不同的分子机制之间的明显相互作用演变，包括串联基因重复形成，分段重复，大规模的基因组重复和广泛的基因损失。
Identifying the mechanisms of eukaryotic genome evolution by comparative genomics is often complicated by the multiplicity of events that have taken place throughout the history of individual lineages, leaving only distorted and superimposed traces in the genome of each living organism. The hemiascomycete yeasts, with their compact genomes, similar lifestyle and distinct sexual and physiological properties, provide a unique opportunity to explore such mechanisms. We present here the complete, assembled genome sequences of four yeast species, selected to represent a broad evolutionary range within a single eukaryotic phylum, that after analysis proved to be molecularly as diverse as the entire phylum of chordates. A total of approximately 24,200 novel genes were identified, the translation products of which were classified together with Saccharomyces cerevisiae proteins into about 4,700 families, forming the basis for interspecific comparisons. Analysis of chromosome maps and genome redundancies reveal that the different yeast lineages have evolved through a marked interplay between several distinct molecular mechanisms, including tandem gene repeat formation, segmental duplication, a massive genome duplication and extensive gene loss.