Getting to the root of plant iron uptake and cell-cell transport: Polarity matters!
Getting to the root of plant iron uptake and cell-cell transport: Polarity matters!
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DOI：
10.1080/19420889.2015.1038441
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发表时间：
2015-05
影响因子：
--
通讯作者：
Vert G
中科院分区：
文献类型：
--
作者：
Dubeaux G;Zelazny E;Vert G
质膜蛋白在介导内源性和环境信号的反应中起着关键作用。膜蛋白水平的调节和极性的建立是许多细胞过程的基础。在植物中，铁调节转运蛋白1 （IRT1）是主要的根铁转运蛋白，但也负责吸收其他二价金属，如锰、锌和钴。我们最近发现，当次生金属底物耗尽时，IRT1极定位于植物根表皮细胞的外质膜结构域。内胞体募集的FYVE1蛋白在内吞噬途径中与IRT1相互作用，并在IRT1极性的建立中发挥关键作用，可能是通过其再循环到细胞表面。我们的工作揭示了营养物质在植物根的不同细胞类型向维管组织的径向运输机制，并提出了与哺乳动物铁运输有趣的相似之处。
Plasma membrane proteins play pivotal roles in mediating responses to endogenous and environmental cues. Regulation of membrane protein levels and establishment of polarity are fundamental for many cellular processes. In plants, IRON-REGULATED TRANSPORTER 1 (IRT1) is the major root iron transporter but is also responsible for the absorption of other divalent metals such as manganese, zinc and cobalt. We recently uncovered that IRT1 is polarly localized to the outer plasma membrane domain of plant root epidermal cells upon depletion of its secondary metal substrates. The endosome-recruited FYVE1 protein interacts with IRT1 in the endocytic pathway and plays a crucial role in the establishment of IRT1 polarity, likely through its recycling to the cell surface. Our work sheds light on the mechanisms of radial transport of nutrients across the different cell types of plant roots toward the vascular tissues and raises interesting parallel with iron transport in mammals.