Modulation of mice anxiety in response to cat odor as a consequence of predators diet
Modulation of mice anxiety in response to cat odor as a consequence of predators diet
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DOI：
10.1016/s0031-9384(98)00126-7
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发表时间：
1998-11-15
影响因子：
2.9
通讯作者：
Belzung, C
中科院分区：
文献类型：
--
作者：
Berton, F;Vogel, E;Belzung, C
评估了捕食者气味作为驱避剂的有效性，并描述了行为抗捕食反应的特征。小鼠可以自由进入一个陌生的跑道含有不同的嗅觉刺激：建模粘土，或粪便的猫进行素食或肉食性饮食。第一个实验揭示了自发行为模式的各种指数，包括探索性活动，不同种类的情绪，以及一系列主动或被动的防御反应，直到出现与焦虑的存在或不存在严格相关的风险评估。这些反应与食肉动物对粪便的反应不同，而不是素食。在第二个实验中，利血平（0，2.5，5，或7.5毫克/公斤）有剂量相关的抗焦虑作用的探索在素食和肉食组的小鼠，但不能完全扭转强烈的焦虑效应肉食刺激防御机制。这些差异与哺乳动物线索的性质有关。这种范式可能是动物焦虑的恐惧动机模型。(C)1998年爱思唯尔科学公司
The effectiveness of predator odours as repellents was assessed, and the behavioral antipredatory responses were characterized. Mice had free access to an unfamiliar runway containing different olfactory stimuli: modelling clay, or feces of a cat subjected either to a vegetarian or a carnivorous diet. The first experiment revealed various indices of a spontaneous behavioral pattern that included exploratory activity, different kinds of emotionality, and a range of active or passive defensive reactions until the appearance of absence of risk assessment strictly related to presence or absence of anxiety. These reactions differ with larger responses to feces resulting from a carnivorous as opposed to vegetarian diets. In the second experiment, chlordiazepoxide (0, 2.5, 5, or 7.5 mg/kg) had a dose-related anxiolytic effect on exploration in mice of both vegetarian and carnivorous groups but could not totally reverse the strong anxiogenic effect of carnivorous stimulus on defensive mechanisms. These differences are related to the nature of the mammalian cues. This paradigm may be a fear-motivated model of animal anxiety. (C) 1998 Elsevier Science Inc.