Structure and evolution of mammalian ribosomal proteins
Structure and evolution of mammalian ribosomal proteins
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DOI：
10.1139/o95-101
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发表时间：
1995-11-01
期刊：
影响因子：
--
通讯作者：
Gluck, A
中科院分区：
文献类型：
--
作者：
Wool, IG;Chan, YL;Gluck, A
哺乳动物（大鼠）核糖体有80种蛋白质，其中75种蛋白质的氨基酸序列已经确定。什么已经学会了大鼠核糖体蛋白质的结构进行审查，特别注意它们的进化和氨基酸序列基序。后者包括：碱性或酸性残基簇;序列重复或共享序列;锌指结构域; bZIP元件;和核定位信号。磷酸化残基和泛素延伸的发生和可能的意义被指出。总结了编码蛋白质的mRNA的特征。整理了大鼠核糖体蛋白与人类、酵母、古细菌和大肠杆菌核糖体蛋白的关系。
Mammalian (rat) ribosomes have 80 proteins; the sequence of amino acids in 75 have been determined. What has been learned of the structure of the rat ribosomal proteins is reviewed with particular attention to their evolution and to amino acid sequence motifs. The latter include: clusters of basic or acidic residues; sequence repeats or shared sequences; zinc finger domains; bZIP elements; and nuclear localization signals. The occurrence and the possible significance of phosphorylated residues and of ubiquitin extensions is noted. The characteristics of the mRNAs that encode the proteins are summarized. The relationship of the rat ribosomal proteins to the proteins in ribosomes from humans, yeast, archaebacteria, and Escherichia coli is collated.