Association of salivary levels of cortisol and dehydroepiandrosterone with periodontitis in older Japanese adults
Association of salivary levels of cortisol and dehydroepiandrosterone with periodontitis in older Japanese adults
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DOI：
10.1902/jop.2007.070044
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发表时间：
2007-09-01
影响因子：
4.3
通讯作者：
Takehara, Tadamichi
中科院分区：
文献类型：
--
作者：
Ishisaka, Aiko;Ansai, Toshihiro;Takehara, Tadamichi
背景：牙周炎与心理神经免疫变量（如应激相关激素）之间的关系尚不清楚。本横断面研究的目的是探讨皮质醇和脱氢表雄酮（DHEA）两种应激相关激素与牙周炎的关系，在健康的社区居住的老年人年龄≥ 60岁。方法：共171人（85名男性和86名女性）参加了这项研究。受试者为独立生活的老年人，平均年龄为68.4（+/- 4.46）岁。收集刺激的全唾液样本，并测定激素水平。还进行了关于医疗状况、生活方式和心理社会压力的医疗问卷调查。临床检查包括探诊深度（PD）、探诊出血和临床附着水平（CAL）。结果：激素水平与PD和CAL值呈正相关。当受试者被分为两组的基础上牙周炎的严重程度，激素水平显着较高的受试者与严重的PD或CAL。多元回归分析表明，较高的皮质醇和DHEA水平与大量的牙齿严重PD或CAL，调整后的混杂变量显着相关。这些结果表明，牙周炎的范围和严重程度与唾液中的皮质醇和DHEA水平在健康的老年人之间的密切关系。据我们所知，这是第一份关于DHEA水平与广泛性牙周炎之间关系的报告。
Background: The relationship between periodontitis and psychoneuroimmunologic variables, such as stress-related hormones, is poorly understood. The purpose of this cross-sectional study was to investigate the associations between two kinds of stress-related hormones, cortisol and dehydroepiandrosterone (DHEA), and periodontitis in healthy community-dwelling elderly subjects aged >= 60 years.Methods: A total of 171 subjects (85 males and 86 females) participated in this study. The subjects were independently living elderly people with a mean age of 68.4 ( +/- 4.46) years. Stimulated whole saliva samples were collected, and hormone levels were determined. A medical questionnaire regarding medical conditions, lifestyle, and psychosocial stress also was administered. The clinical examinations included probing depth (PD), bleeding on probing, and clinical attachment level (CAL).Results: There was a positive correlation between hormone levels and PD and CAL values. When the subjects were divided into two groups based on periodontitis severity, hormone levels were significantly higher in subjects with severe PD or CAL. Multiple regression analysis showed that higher cortisol and DHEA levels were associated significantly with greater numbers of teeth with severe PD or CAL, after adjusting for confounding variables.Conclusions: These results suggested close relationships between the extent and severity of periodontitis and salivary levels of cortisol and DHEA in healthy elderly subjects. To the best of our knowledge, this is the first report on the association between the levels of DHEA and extensive periodontitis.