Hepatoprotective potential of ethanolic extract of Aquilaria agallocha leaves against paracetamol induced hepatotoxicity in SD rats.
Hepatoprotective potential of ethanolic extract of Aquilaria agallocha leaves against paracetamol induced hepatotoxicity in SD rats.
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DOI：
10.1016/j.jtcme.2015.12.006
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发表时间：
2017-01-01
影响因子：
4.5
通讯作者：
Rahman, Md Azizur
中科院分区：
文献类型：
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作者：
Alam, Janey;Mujahid, Md;Rahman, Md Azizur
许多传统的药物系统采用草药来保护肝脏。研究沉香叶醇提物（AAE）对对乙酰氨基酚（PCM）肝毒性的保护作用。组I动物用1% CMC处理8天。Ⅱ、Ⅲ、Ⅳ、Ⅴ组分别用1% CMC 1 ml/kg/d、AAE 200 mg/kg/d、AAE 400 mg/kg/d、水飞蓟素100 mg/kg/d灌胃7天后，再用PCM 3g/kg B灌胃。重量第8天，单剂量。PCM末次给药后24小时，在轻度麻醉下通过眶后丛采血，并处死动物。通过各种生化指标如ALT、AST、ALP、LDH、胆红素、胆固醇、TP和ALB来评估肝保护能力。
Many traditional systems of medicines employ herbal drugs for the hepatoprotection. Aim of the study was designed to evaluate the hepatoprotective potential of 'ethanolic extract of Aquilaria agallocha ( Chen Xiang) leaves' (AAE) against paracetamol (PCM) induced hepatotoxicity in SD rats. Group I animals were treated with 1% CMC for 8 days. Group II, III, IV and V animals were first treated with '1% CMC' 1ml/kg/day, AAE 200mg/kg/day, AAE 400mg/kg/day and silymarin 100mg/kg/day respectively for 7 days and then, orally administered with PCM 3g/kg b. wt. on 8th day in a single dose. 24h after the last dosing by PCM, the blood was obtained through the retro-orbital plexus under light anesthesia and the animals were sacrificed. Hepatoprotective potential was assessed by various biochemical parameters such as ALT, AST, ALP, LDH, bilirubin, cholesterol, TP and ALB. Group IV rats showed significant (p