Evidence of reuptake inhibition responsible for mecamylamine-evoked increases in extracellular serotonin.
Evidence of reuptake inhibition responsible for mecamylamine-evoked increases in extracellular serotonin.
复制标题
有证据表明，再摄取抑制是美加明引起的细胞外血清素增加的原因。
DOI：
10.1016/j.brainres.2005.12.080
复制
发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Tao,Rui
中科院分区：
文献类型：
--
作者：
Ma,Zhiyuan;Pearson,Elliot;Isgor,Ceylan;Tao,Rui
本文采用微透析技术研究了美加明对自由活动大鼠中缝背核细胞外5-羟色胺的神经化学调节机制。这些结果表明，美加明可能会阻止5-羟色胺的再摄取，这种作用与其抗抑郁作用一致。
The present report using microdialysis approach investigates the neurochemical mechanism of mecamylamine in the regulation of extracellular serotonin in the dorsal raphe nucleus of freely behaving rats. These results suggest that mecamylamine may block serotonin reuptake, the effect consistent with its efficacy of antidepressant.