Recognition and rapid diagnosis of upper gastrointestinal cytomegalovirus infection in marrow transplant recipients. A comparison of seven virologic methods.
Recognition and rapid diagnosis of upper gastrointestinal cytomegalovirus infection in marrow transplant recipients. A comparison of seven virologic methods.
复制标题
骨髓移植受者上消化道巨细胞病毒感染的识别和快速诊断。
DOI：
10.1097/00007890-199401001-00014
复制
发表时间：
1994
期刊：
影响因子：
6.2
通讯作者：
McDonald,GB
中科院分区：
文献类型：
--
作者：
Hackman,RC;Wolford,JL;Gleaves,CA;Myerson,D;Beauchamp,MD;Meyers,JD;McDonald,GB
这是一项回顾性研究，对54例骨髓移植受者进行连续上消化道内镜检查，以确定有症状患者CMV感染的发生率和分布，并比较7种CMV检测技术的敏感性。在每次内窥镜检查时，从食管、胃和十二指肠获得3份活检。通过不同的技术测定3个活检组织中的每一个的CMV。在14例感染患者的486例活检中，有52例（11%）通过一种或多种技术确定了肠道CMV。所有感染CMV的患者最初都有恶心和呕吐。在这些患者中，有13例食管CMV，通常与胃（10例）和十二指肠（7例）的参与。CMV感染的食管从来没有确定细胞学上的食管印记或组织学，免疫组织学，或DNA杂交在食管上皮细胞。最敏感的诊断
This is a retrospective study of 54 consecutive upper gastrointestinal endoscopies in marrow graft recipients performed to determine the incidence and distribution of CMV infection in symptomatic patients and to compare the sensitivities of 7 CMV detection techniques. At each endoscopy, 3 biopsies were obtained from the esophagus, stomach, and duodenum. Each of the 3 biopsies was assayed for CMV by different techniques. Enteric CMV was identified by one or more techniques in 52 of 486 (11%) biopsies from 14 infected patients. All patients infected with CMV initially had nausea and vomiting. In 13 of these patients, there was esophageal CMV, often associated with stomach (10 patients) and duodenal (7 patients) involvement. CMV infection of the esophagus was never identified cyto-logically in esophageal imprints or histologically, immunohistologically, or by DNA hybridization in esophageal epithelial cells. The most sensitive diag