DESCRIPTION OF THE OCCLUSION OF THE SPINAL-CORD LUMEN IN EARLY HUMAN-EMBRYOS
DESCRIPTION OF THE OCCLUSION OF THE SPINAL-CORD LUMEN IN EARLY HUMAN-EMBRYOS
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DOI：
10.1002/ar.1092040112
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发表时间：
1982-01-01
影响因子：
--
通讯作者：
DESMOND, ME
中科院分区：
文献类型：
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作者：
DESMOND, ME
之前对鸡和人类胚胎的研究表明，一旦神经管成为一个封闭的、充满液体的系统，大脑就会迅速扩大。在这种扩大之前，脊髓的内侧壁看起来是融合的，阻塞了管腔。管腔闭塞是根据其发生率、沿神经轴的位置、发生时间、发生持续时间和人类胚胎的形态来描述的。对来自卡内基收藏馆的人类胚胎(82个)(阶段9-15)进行了分析。闭塞首先发生在11期胚胎中(并且是最常见的)，在13期以上的胚胎中不存在。在所有被检查的病例中，神经轴从第三对体节水平到至少第九对体节水平(即apprx)显示不间断的闭塞。60%的神经轴闭塞)。受阻神经管在横断面上的外观类似于S手指间夹着的汽水吸管。
Previous studies of both chick and human embryos showed that the brain enlarges rapidly once the neural tube becomes a closed, fluid-filled system. Prior to such enlargement, the medial walls of the spinal cord appear fused, occluding the lumen. Occlusion of the lumen is described in terms of its incidence, location along the neuroaxis, time of occurrence, duration of occurrence and morphology in human embryos. Human embryos (82) (stages 9-15) from the Carnegie Collection were analyzed. Occlusion first occurs (and is most prevalent) in stage 11 embryos and is absent in embryos older than stage 13. In all cases examined, the neuroaxis demonstrated uninterrupted occlusion from the level of the 3rd pair of somites to at least the 9th pair (i.e., .apprx. 60% of the neuroaxis was occluded). The appearance of the occluded neural tube in cross sections is similar to that of a soda straw pinched between one''s fingers.