Dynamics of excitatory and inhibitory networks are differentially altered by selective attention.
Dynamics of excitatory and inhibitory networks are differentially altered by selective attention.
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DOI：
10.1152/jn.00343.2016
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发表时间：
2016-07
影响因子：
2.5
通讯作者：
A. Snyder;Michael J. Morais;M. A. Smith
中科院分区：
文献类型：
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作者：
A. Snyder;Michael J. Morais;M. A. Smith
抑制和兴奋是神经元相互作用的两种基本模式，但我们对它们在知觉和认知过程中的独特作用知之甚少。我们开发了一种多维波形分析方法来识别体内快速尖峰（假定为抑制性）和常规尖峰（假定为兴奋性）神经元，并利用这种方法分析了注意力如何影响恒河猴纹外皮层V4视觉区这两类细胞。我们发现，与假设的兴奋性神经元相比，假设的抑制性神经元的放电率增加更大，与注意相关的变异性减少。此外，假设的抑制性神经元的注意效应的时间过程更密切地跟踪了我们任务中目标概率的时间统计。最后，注意力行为测量的会话间可变性与这种效应的大小共变。总之，这些结果表明选择性靶向抑制性神经元和网络是注意调节的关键机制。
Inhibition and excitation form two fundamental modes of neuronal interaction, yet we understand relatively little about their distinct roles in service of perceptual and cognitive processes. We developed a multidimensional waveform analysis to identify fast-spiking (putative inhibitory) and regular-spiking (putative excitatory) neurons in vivo and used this method to analyze how attention affects these two cell classes in visual area V4 of the extrastriate cortex of rhesus macaques. We found that putative inhibitory neurons had both greater increases in firing rate and decreases in correlated variability with attention compared with putative excitatory neurons. Moreover, the time course of attention effects for putative inhibitory neurons more closely tracked the temporal statistics of target probability in our task. Finally, the session-to-session variability in a behavioral measure of attention covaried with the magnitude of this effect. Together, these results suggest that selective targeting of inhibitory neurons and networks is a critical mechanism for attentional modulation.