Cognitive-behavioral stress management increases benefit finding and immune function among women with early-stage breast cancer
Cognitive-behavioral stress management increases benefit finding and immune function among women with early-stage breast cancer
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DOI：
10.1016/s0022-3999(03)00036-9
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发表时间：
2004-01-01
影响因子：
4.7
通讯作者：
Carver, CS
中科院分区：
文献类型：
--
作者：
McGregor, BA;Antoni, MH;Carver, CS
目的：本研究探讨认知-行为压力管理(CBSM)干预对早期乳腺癌术后数月女性的情绪幸福感和免疫功能的影响。方法：29名女性被随机分配接受为期10周的CBSM干预(n=18)或对照体验(n=11)。主要的心理结果指标是受益发现：主要的免疫功能结果指标是体外淋巴细胞对抗CD3的增殖反应。结果：与对照组相比，接受CBSM干预的女性报告说，她们对乳腺癌的益处有更多的认知。在3个月的随访中，CBSM组的妇女淋巴细胞增殖也有所改善。最后，在干预10周后，受益发现的增加预测了3个月随访时淋巴细胞增殖的增加。结论：CBSM对早期乳腺癌妇女的干预促进了她们对乳腺癌经历的积极情绪反应，同时也促进了后来细胞免疫功能的改善。(C)2004 Elsevier Inc.保留所有权利。
Objective: This study examined the effect of a cognitive-behavioral stress management (CBSM) intervention on emotional well-being and immune function among women in the months following surgery for early-stage breast cancer. Method: Twenty-nine women were randomly assigned to receive either a 10-week CBSM intervention (n = 18) or a comparison experience (n = 11). The primary psychological outcome measure was benefit finding: The primary immune function outcome measure was in vitro lymphocyte proliferative response to anti CD3. Results: Women in the CBSM intervention reported greater perceptions of benefit from having breast cancer compared to the women in the comparison group. At 3-month follow-up, women in the CBSM group also had improved lymphocyte proliferation. Finally, increases in benefit finding after the 10-week intervention predicted increases in lymphocyte proliferation at the 3-month follow-up. Conclusion: A CBSM intervention for women with early-stage breast cancer facilitated positive emotional responses to their breast cancer experience in parallel with later improvement in cellular immune function. (C) 2004 Elsevier Inc. All rights reserved.