New Diffusion Phantoms Dedicated to the Study and Validation of High-Angular-Resolution Diffusion Imaging (HARDI) Models
New Diffusion Phantoms Dedicated to the Study and Validation of High-Angular-Resolution Diffusion Imaging (HARDI) Models
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DOI：
10.1002/mrm.21789
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发表时间：
2008-12-01
影响因子：
3.3
通讯作者：
Mangin, Jean-Francois
中科院分区：
文献类型：
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作者：
Poupon, Cyril;Rieul, Bernard;Mangin, Jean-Francois
我们提出了新的扩散幻影，致力于研究和验证高角分辨率扩散成像（HARDI）模型。幻影设计允许成像参数的应用，通常用于人脑的研究。这些假体由小直径的丙烯酸纤维制成，因为它们的高疏水性和灵活性确保了假体几何形状的良好控制。在真空条件下，用事先脱气的水溶液填充聚氨酯介质，掺杂钆-四氮杂环十二烷四乙酸（Gd-DOTA），并进行超声波处理。制造和测试了两种版本的这种幽灵。在分析型q球模型上验证了该模型的适用性。通过数值模拟来评估模型的准确性。幻影数据将提供给社区，目的是分析各种HARDI模型。中华医学杂志，2008,31(2):376 - 383。(C) 2008 Wiley-Liss, Inc。
We present new diffusion phantoms dedicated to the study and validation of high-angular-resolution diffusion imaging (HARDI) models. The phantom design permits the application of imaging parameters that are typically employed in studies of the human brain. The phantoms were made of small-diameter acrylic fibers, chosen for their high hydrophobicity and flexibility that ensured good control of the phantom geometry. The polyurethane medium was filled under vacuum with an aqueous solution that was previously degassed, doped with gadolinium-tetraazacyclododecanetetraacetic acid (Gd-DOTA), and treated by ultrasonic waves. Two versions of such phantoms were manufactured and tested. The phantom's applicability was demonstrated on an analytical Q-ball model. Numerical simulations were performed to assess the accuracy of the phantom. The phantom data will be made accessible to the community with the objective of analyzing various HARDI models. Magn Reson Med 60:1276-1283, 2008. (C) 2008 Wiley-Liss, Inc.