BARTONELLA HENSELAE - ETIOLOGY OF PULMONARY NODULES IN A PATIENT WITH DEPRESSED CELL-MEDIATED-IMMUNITY
BARTONELLA HENSELAE - ETIOLOGY OF PULMONARY NODULES IN A PATIENT WITH DEPRESSED CELL-MEDIATED-IMMUNITY
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DOI：
10.1093/clinids/20.6.1505
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发表时间：
1995-06-01
影响因子：
11.8
通讯作者：
BLITCHINGTON, RB
中科院分区：
文献类型：
--
作者：
CANIZA, MA;GRANGER, DL;BLITCHINGTON, RB
我们描述了一例免疫受损的肾移植患者，由于亨氏巴尔通体(以前的亨氏罗氏杆菌)而发生机会性肺部感染，并提供了证据表明是由宠物猫传播的。胸部和肺活检的计算机断层扫描为诊断提供了材料。通过聚合酶链式反应和对感染肺组织的16S核糖体DNA片段进行测序，确定了病原学。组织病理学和血清学证据支持分子数据。从病人的许多猫中的8只的血液中分离出亨塞氏双胞菌。患者对多西环素延长治疗有反应，在一年的随访期内没有复发。亨氏杆菌是与细胞介导的免疫缺陷状态相关的可导致肺部感染的一长串病原体之一。鉴于细菌挑剔的生长特性，分子方法在这种感染的诊断中是有用的。如果免疫功能低下的患者有肺结节和猫暴露史，应该在活检标本中寻找亨塞氏双胞菌。
We describe an immunocompromised renal transplantation patient with opportunistic lung infection due to Bartonella henselae (formerly Rochalimaea henselae) and provide evidence suggesting transmission from a pet cat. Computed tomographic scans of the chest and lung biopsies provided material for diagnosis. The etiology was established by polymerase chain reaction and sequencing of a 16S ribosomal DNA segment from infected lung tissue. Histopathologic and serological evidence supported the molecular data. B. henselae was isolated from the blood of eight of the patient's many cats. The patient responded to prolonged therapy with doxycycline, and relapse did not occur during a 1-year follow-up. B. henselae joins a long list of pathogens that can cause lung infections in association with cell-mediated immunodeficiency states. Molecular methods are useful in diagnosis of this infection in light of the bacterium's fastidious growth characteristics. If an immunocompromised patient has lung nodules and a history of exposure to cats, B. henselae should be sought in biopsy specimens.