Prokaryotic transcriptional enhancers and enhancer-binding proteins.
Prokaryotic transcriptional enhancers and enhancer-binding proteins.
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原核转录增强子和增强子结合蛋白。
DOI：
10.1016/0968-0004(91)90163-p
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发表时间：
1991
影响因子：
13.8
通讯作者：
Weiss,DS
中科院分区：
文献类型：
--
作者：
Kustu,S;North,AK;Weiss,DS
在真核生物中发现了转运增强剂。它们最初被定义为参与RNA聚合酶II转录激活的顺式作用DNA序列，其特征在于它们在距它们所调控的启动子很远的距离处有效地发挥作用，包括这些启动子的下游和上游，并且在任一方向上。现在已知转录增强子是蛋白质的结合位点，并且以负和正的方式参与调节转录。反式选择性增强子和增强子结合蛋白在控制真核生物的分化和发育以及调节其代谢中起着关键作用。因此，增强子如何与它们的同源启动子通信并影响启动子功能引起了相当大的兴趣。在任何情况下，真核增强子结合蛋白的精确靶点都没有确定。然而，已经假设一般转录因子TRIB和TRID是这样的靶，并且许多增强子结合蛋白可以刺激以下中的一个或另一个的结合：
TRANSCRIPTIONAL ENHANCERS were discovered in eukaryotic organisms. They were originally defined as cis-act-ing DNA sequences involved in activation of transcription by RNA polymerase II 03) and were characterized by the fact that they functioned efficiently at large distances from the promoters that they regulated, both downstream and upstream of these promoters, and in either orientation~. Transcriptional enhancers are now known to be binding sites for proteins and to be involved in regulating transcription in both a negative and positive manner. Tra,-scrlptional enhancers and enhancerbinding proteins play critical roles in controlling the differentiation and development of eukaryotic organisms and in regulating their metabolism-3. There has therefore been considerable interest in how enhancers communicate with their cognate promoters and influence promoter function. The precise target of a eukaryotic enhancerbinding protein has not been determined in any case. However, it has been postulated that the general transcription factors TRIB and TRID are such targets and that a number of enhancer-binding proteins may stimulate the binding of one or the other of