Cannabinoid CB1 receptor inhibition decreases vascular smooth muscle migration and proliferation.
Cannabinoid CB1 receptor inhibition decreases vascular smooth muscle migration and proliferation.
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DOI：
10.1016/j.bbrc.2008.10.159
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发表时间：
2008-12-26
影响因子：
3.1
通讯作者：
Pacher, Pal
中科院分区：
文献类型：
--
作者：
Rajesh, Mohanraj;Mukhopadhyay, Partha;Hasko, Gyoergy;Pacher, Pal
关键词：
由炎症刺激物和化学引诱物如血小板衍生生长因子（PDGF）触发的血管平滑肌增殖和迁移是动脉粥样硬化和再狭窄的发展和进展中的关键事件。大麻素可通过大麻素受体调节各种细胞类型中的细胞增殖和迁移。在这里，我们研究了CB 1受体拮抗剂利莫那班（SR 141716 A），最近已被证明有抗动脉粥样硬化的作用，在小鼠和人类对PDGF诱导的增殖，迁移和信号转导的人冠状动脉平滑肌细胞（HCASMCs）。PDGF诱导Ras和ERK 1/2活化，同时增加HCASMCs的增殖和迁移，CB 1拮抗剂利莫那班呈剂量依赖性地减弱。这些结果表明，除了改善血脂的变化和减少炎症细胞迁移和炎症反应，CB 1拮抗剂可能发挥有益的作用，在动脉粥样硬化和再狭窄，减少血管平滑肌增殖和迁移。
Vascular smooth muscle proliferation and migration triggered by inflammatory stimuli and chemoattractants such as platelet-derived growth factor (PDGF) are key events in the development and progression of atherosclerosis and restenosis. Cannabinoids may modulate cell proliferation and migration in various cell types through cannabinoid receptors. Here we investigated the effects of CB1 receptor antagonist rimonabant (SR141716A), which has recently been shown to have anti-atherosclerotic effects both in mice and humans on PDGF-induced proliferation, migration, and signal transduction of human coronary artery smooth muscle cells (HCASMCs). PDGF induced Ras and ERK 1/2 activation, while increasing proliferation and migration of HCASMCs, which were dose-dependently attenuated by CB1 antagonist, rimonabant. These findings suggest that in addition to improving plasma lipid alterations and decreasing inflammatory cell migration and inflammatory response, CB1 antagonists may exert beneficial effects in atherosclerosis and restenosis by decreasing vascular smooth muscle proliferation and migration.
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影响因子：
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作者：
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通讯作者：
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DOI：
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影响因子：
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