Tissue Failure Propagation as Mediated by Circulatory Flow
Tissue Failure Propagation as Mediated by Circulatory Flow
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DOI：
10.1016/j.bpj.2020.11.004
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发表时间：
2020-12-15
影响因子：
3.4
通讯作者：
Vural，Dervis Can
中科院分区：
文献类型：
--
作者：
Uppal，Gurdip;Bahcecioglu，Gokhan;Vural，Dervis Can
衰老是由亚细胞过程驱动的，这一过程相对来说已经被很好地理解了。然而，这些微观层面的故障如何级联到组织或器官的宏观层面的灾难的定性机制和定量动力学在很大程度上仍未被探索。在这里，我们从实验和理论上研究了在平流存在的情况下，细胞衰竭是如何在工程组织中传播的。我们认为细胞分泌合作因子，从而形成一个由扩散和流动控制的相互依赖网络，该网络与平行于平流循环的传播锋失败。
Aging is driven by subcellular processes that are relatively well understood. However, the qualitative mechanisms and quantitative dynamics of how these micro-level failures cascade to a macro-level catastrophe in a tissue or organs remain largely unexplored. Here, we experimentally and theoretically study how cell failure propagates in an engineered tissue in the presence of advective flow. We argue that cells secrete cooperative factors, thereby forming a network of interdependence governed by diffusion and flow, which fails with a propagating front parallel to advective circulation.