Autophagy is a cell survival program for female germ cells in the murine ovary
Autophagy is a cell survival program for female germ cells in the murine ovary
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DOI：
10.1530/rep-10-0489
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发表时间：
2011-06-01
期刊：
影响因子：
3.8
通讯作者：
Rucker, Edmund B., III
中科院分区：
文献类型：
--
作者：
Gawriluk, Thomas R.;Hale, Amber N.;Rucker, Edmund B., III
据估计，不孕症影响15-20%的夫妇，可能由女性或男性生殖缺陷引起。小鼠模型已经将维持女性生育能力的作用归因于100多个基因。虽然以前的模型已经确定了细胞凋亡在男性和女性生育能力中的作用，但我们发现，通过Becn 1或Atg 7的丢失，围产期卵巢内的自噬受损，导致女性生殖细胞的过早丢失。Becn 1（+/-）卵巢在出生后第1天与对照卵巢相比生殖细胞减少了56%，而Atg 7（-/-）卵巢在此阶段缺乏可辨别的生殖细胞。因此，自噬似乎是一种细胞生存机制，以维持在卵巢中建立原始卵泡池之前的雌性生殖细胞的禀赋。生殖（2011年）141 759-765
It is estimated that infertility affects 15-20% of couples and can arise from female or male reproductive defects. Mouse models have ascribed roles to over 100 genes in the maintenance of female fertility. Although previous models have determined roles for apoptosis in male and female fertility, we find that compromised autophagy within the perinatal ovary, through the loss of Becn1 or Atg7, results in the premature loss of female germ cells. Becn1(+/-) ovaries have a 56% reduction of germ cells compared with control ovaries at post-natal day 1, whereas Atg7(-/-) ovaries lack discernable germ cells at this stage. Thus autophagy appears to be a cell survival mechanism to maintain the endowment of female germ cells prior to establishing primordial follicle pools in the ovary. Reproduction (2011) 141 759-765