Ethanol-induced changes in morphology and strength of femurs of rats.
Ethanol-induced changes in morphology and strength of femurs of rats.
复制标题
乙醇引起大鼠股骨形态和强度的变化。
DOI：
10.1111/j.1530-0277.1988.tb00260.x
复制
发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Hagaman,JR
中科院分区：
文献类型：
--
作者：
Peng,TC;Kusy,RP;Hirsch,PF;Hagaman,JR
长期摄入乙醇导致大鼠股骨超微结构和力学变化。股骨远端扫描电镜显示，与对照组相比，乙醇喂养大鼠的骨小梁更薄、柱状、更广泛。大鼠股骨的三点弯曲试验表明，在乙醇中折断骨头所需的最大力或所谓的“强度”比对照组喂养的动物要小。在折断股骨所需的力量和以体重为基础计算的乙醇剂量之间观察到显著的负相关。我们的研究首次提供了定量证据，证明骨强度与大鼠乙醇消耗量之间存在关系。研究表明，与对照组相比，酒精摄入导致股骨变弱。我们认为，一个共同的机制可能是造成乙醇喂养大鼠骨强度下降和人类酗酒者骨折发生率增加的原因。
Chronic ingestion of ethanol resulted in ultrastructural and mechanical changes in rat femurs. Scanning electron microscopy of the distal end of the femur revealed that the trabeculae of bones from ethanol‐fed rats were thinner, more columnar, and more extensive than those from control rats. Three‐point bending tests of the rat femurs showed that the maximum force or so‐called “strength” required to break the bone was less in ethanol‐ than in control‐fed animals. A significant inverse correlation was observed between the strength required to break the femur and the dose of ethanol calculated on a body weight basis.For the first time our study presents quantitative proof that a relationship exists between bone strength and the consumption of ethanol in rats. The study revealed that ethanol consumption resulted in a weaker femur compared to controls. We suggest that a common mechanism may be responsible for the decreased bone strength of ethanol‐fed rats and the increased incidence of fractures in human alcoholics.