The relationship between promoter methylation of p16 gene and bladder cancer risk: a meta-analysis.
The relationship between promoter methylation of p16 gene and bladder cancer risk: a meta-analysis.
复制标题
p16 基因启动子甲基化与膀胱癌风险之间的关系：荟萃分析。
DOI：
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发表时间：
2015-11
影响因子：
0.1
通讯作者：
Ji, Weidong
中科院分区：
文献类型：
--
作者：
Li, Mengxi;Su, Jialin;Que, Biao;Ji, Weidong
PURPOSE
Many scientific evidences suggested that the methylation of p16INK4a (p16) was associated with bladder cancer, but some existing studies have yielded inconclusive results about the relationship between p16 promoter methylation and pathological features or the tumor grade of bladder cancer. This meta-analysis of studies aims to evaluate the clinical and prognostic significance of p16 methylation in bladder carcinogenesis.
METHODS
Studies were systemically searched via PubMed and Google Scholar in English up to Sept 2015 and a total of ten appropriate studies (693 cases and 290 controls) with an average NOS score of 6.8 were included. The quality of the appropriate studies was measured by the Newcastle-Ottawa Scale (NOS) assessment.
RESULTS
The meta-analysis results revealed that the methylation state of p16 was statistically significantly associated with an increased risk of bladder cancer (OR=6.71, 95% CI=3.79-11.87) compared to control, and there is no statistically significantly association between the p16 methylation and the tumor pTNM staging (OR=0.59, 95% CI=0.22-1.60) or the tumor grade (OR=1.01, 95% CI=0.52-1.94) in p16 methylated patients compared to unmethylated patients.
CONCLUSIONS
our meta-analysis indicates that p16 promoter methylation may be a promising biomarker for the diagnosis of bladder cancer and the inactivation of p16 may be an early event in bladder carcinogenesis. More studies with larger numbers of participants worldwide are needed to further identify the obvious association above.
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影响因子：
5.8
作者：
Zintzaras, E;Ioannidis, JPA
通讯作者：
Ioannidis, JPA
影响因子：
2
作者：
Jackson, Dan;White, Ian R.;Riley, Richard D.
通讯作者：
Riley, Richard D.
DOI：
--
发表时间：
2002-02
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
M. Chan;L. Chan;N. Tang;J. Tong;K. Lo;Tin L. Lee;H. Cheung;W. Wong;P. Chan;F. M. Lai-F.-M.-L
通讯作者：
M. Chan;L. Chan;N. Tang;J. Tong;K. Lo;Tin L. Lee;H. Cheung;W. Wong;P. Chan;F. M. Lai-F.-M.-L
影响因子：
11.2
作者：
P. Jones
通讯作者：
P. Jones
影响因子：
11.2
作者：
R. Maruyama;S. Toyooka;Kiyomi O. Toyooka;K. Harada;A. Virmani;S. Zöchbauer-Müller;Alfredo J. Farinas;F. Vakar‐López;J. Minna;A. Sagalowsky;B. Czerniak;A. Gazdar
通讯作者：
R. Maruyama;S. Toyooka;Kiyomi O. Toyooka;K. Harada;A. Virmani;S. Zöchbauer-Müller;Alfredo J. Farinas;F. Vakar‐López;J. Minna;A. Sagalowsky;B. Czerniak;A. Gazdar