CORTISOL AND BEHAVIORAL-RESPONSES TO REPEATED STRESSORS IN THE HUMAN NEWBORN
CORTISOL AND BEHAVIORAL-RESPONSES TO REPEATED STRESSORS IN THE HUMAN NEWBORN
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DOI：
10.1002/dev.420240704
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发表时间：
1991-11-01
影响因子：
2.2
通讯作者：
RIGATUSO, J
中科院分区：
文献类型：
--
作者：
GUNNAR, MR;HERTSGAARD, L;RIGATUSO, J
这份手稿报告了每隔24小时重复一次的应激源对三个人类新生儿样本的影响。在研究1中，符合产科和围产期最佳标准的新生儿经历了两次模拟出院检查，被视为一种处理应激源，或两次脚跟抽血，被视为一种伤害性应激源。与之前的研究一样，符合最佳标准的新生儿表现出对重复出院检查的肾上腺皮质反应的习惯性。肾上腺皮质对重复的高跟棒的反应有增加或敏化的趋势。在研究2和研究3中，检查了产科并发症评分较多的新生儿样本。这些新生儿没有表现出对出院检查的肾上腺皮质反应的习惯性，但对重复使用脚跟棒的反应就像“最佳”新生儿。讨论了Groves和Thompson(1970)双过程习惯化模型对这些数据的适用性。这一结果也提供了行为困扰的稳定性与肾上腺皮质活动的稳定性无关的证据。这些数据对于使用皮质醇作为早期气质的生理基础的指数的研究的意义被考虑。
This manuscript reports on the effects of stressors repeated at a 24-hr interval on three samples of human newborns. In Study 1, newborns meeting criteria for obstetric and perinatal optimality experienced either 2 mock Discharge Exams, viewed as a type of handling stressor, or 2 Heelstick Blood Draws, viewed as a type of nocioceptive stressor. As in a previous study, newborns meeting optimality criteria showed habituation of the adrenocortical response to the repeated Discharge Exam. The adrenocortical response to the repeated Heelstick tended to increase or sensitize. In Studies 2 and 3, samples of newboms with more nonoptimal obstetric complication scale scores were examined. These newborns failed to show habituation of the adrenocortical response to the Discharge Exam, but responded like "Optimal" newborns to the repeated Heelstick. The applicability to these data of the Groves and Thompson (1970) Dual-Process Model of Habituation is discussed. The results also provided evidence of stability in behavioral distress independent of stability in adrenocortical activity. The implications of these data for studies using cortisol as an index of the physiological basis of early temperament are considered.