Vitamin A supplements are well tolerated with the pentavalent vaccine
Vitamin A supplements are well tolerated with the pentavalent vaccine
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DOI：
10.1016/j.vaccine.2008.09.037
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发表时间：
2008-12-02
期刊：
影响因子：
5.5
通讯作者：
Kirkwood, Betty R.
中科院分区：
文献类型：
--
作者：
Newton, Sam;Owusu-Agyei, Seth;Kirkwood, Betty R.
扩大免疫接种方案提供了向幼儿提供维生素A补充剂的机会，以改善他们的维生素A状况。然而，发展中国家对6个月以下婴儿服用大剂量维生素A补充剂的安全性提出了担忧。金坦波健康研究中心进行了一项随机对照试验，以评估在6、10和14周大的婴儿在接种五价“白喉-脊髓灰质炎-破伤风-流感嗜血杆菌乙型肝炎疫苗”的同时接种15毫克视黄醇当量(RE)(1)维生素A的安全性和免疫原性。根据国家政策，所有母亲都接受了120毫克稀土维生素A的产后补充。已接种疫苗的婴儿的母亲在接种疫苗后24小时进行访问，以评估疫苗的副作用。他们还就孩子接种疫苗后过去4周可能发生的不良事件进行了采访。与对照组的婴儿相比，服用维生素A的婴儿的疾病和发烧报告明显减少。根据世卫组织/计划免疫计划，在婴儿接种6、10和14周时，五价疫苗被发现可以耐受维生素A。孩子的母亲提出的投诉很少，被认为与疫苗一起服用维生素A无关。试验中有6例死亡，干预组5例，对照组1例，RR为4.65(0.55-39.5)，p=0.12。由于4.65的最高估计值，我们希望敦促在6、10和14周龄使用五价疫苗的年轻婴儿服用大剂量维生素A时要谨慎。(C)2008爱思唯尔有限公司。保留所有权利。
The Expanded Programme on immunisation provides an opportunity to deliver vitamin A Supplements to young infants in order to improve their vitamin A status. However, concerns have been raised about the safety of administering high dose vitamin A supplements to infants less than 6 months of age in developing countries.A randomized controlled trial was carried out by the Kintampo, Health Research Centre to assess the safety and immunogenicity of administering 15 mg retinol equivalent (RE)(1) vitamin A alongside the pentavalent "diphtheria-polio-tetanus-Haemophilus influenzae b-hepatitis B vaccine" at 6, 10 and 14 weeks of age. All mothers received a post-partum supplement of 120 mg RE vitamin A as per national policy. Mothers of infants who had been vaccinated were visited 24 h after vaccination to assess the side effects of the vaccine. They were also interviewed about adverse events which may have occurred in the past 4 weeks since the child was vaccinated. There were significantly fewer reports of illnesses and fever in infants who had been given vitamin A compared to infants in the control group. The pentavalent vaccine Was found to be tolerable when administered with vitamin A according to the WHO/EPI schedule for infant immunisation at 6, 10 and 14 weeks. There were few complaints made by the mothers of the children which were not thought to be related to giving vitamin A with the vaccines. There were six deaths in the trial, five in the intervention group and one in the control RR 4.65 (0.55-39.5), p=0.12. Due to the high point estimate of 4.65, we wish to urge caution in administering high doses of vitamin A to Young infants with the pentavalent vaccine at 6, 10 and 14 weeks of age. (C) 2008 Elsevier Ltd. All rights reserved.