Race-Ethnic and Sex Differences in Left Ventricular Structure and Function: The Coronary Artery Risk Development in Young Adults (CARDIA) Study
Race-Ethnic and Sex Differences in Left Ventricular Structure and Function: The Coronary Artery Risk Development in Young Adults (CARDIA) Study
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DOI：
10.1161/jaha.114.001264
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发表时间：
2015-03-01
影响因子：
5.4
通讯作者：
Lima, Joao A. C.
中科院分区：
文献类型：
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作者：
Kishi, Satoru;Reis, Jared P.;Lima, Joao A. C.
背景-我们调查了43 - 55岁的非裔美国人和白色男性和女性的左心室（LV）结构和LV功能的种族-种族和性别特异性关系。方法和结果-年轻人冠状动脉风险发展（CARDIA）研究招募了非裔美国人和白色成人，年龄18 - 30岁，来自1985-1986年（0年）的4个美国现场中心，已进行前瞻性随访。我们纳入了在25岁考试时进行超声心动图评估的参与者（n=3320; 44%男性，46%非裔美国人）。采用常规超声心动图和斑点追踪超声心动图评价左室结构和功能终点。在多变量模型中，我们除了使用种族-民族和性别术语外，还使用人口统计学术语。（年龄，体力活动和教育水平）和心血管风险变量（体重指数、收缩压、舒张压、心率、糖尿病的存在、抗高血压药物的使用，吸烟数量/天）作为25年检查时超声心动图结局的独立预测因素（LV舒张末期容积[LVEDV]/身高、LV收缩末期容积[LVESV]/身高、LV质量[LVM]/身高和LV结构指数的LVM/LVEDV比值; LV收缩指数的LV射血分数[LVEF]、Ell和Ecc;舒张早期与心房早期比值、二尖瓣环早期峰值流速、二尖瓣早期峰值流速/二尖瓣环早期峰值流速比值;比率、左心房容积/高度、舒张指数的纵向峰值舒张早期应变率和周向峰值舒张早期应变率）。与女性相比，非裔美国人和白色男性的左心室容积和左心室质量更大（P
Background-We investigated race-ethnic and sex-specific relationships of left ventricular (LV) structure and LV function in African American and white men and women at 43 to 55 years of age.Methods and Results-The Coronary Artery Risk Development in Young Adults (CARDIA) Study enrolled African American and white adults, age 18 to 30 years, from 4 US field centers in 1985-1986 (Year-0) who have been followed prospectively. We included participants with echocardiographic assessment at the Year-25 examination (n=3320; 44% men, 46% African American). The end points of LV structure and function were assessed using conventional echocardiography and speckle-tracking echocardiography. In the multivariable models, we used, in addition to race-ethnic and gender terms, demographic (age, physical activity, and educational level) and cardiovascular risk variables (body mass index, systolic blood pressure, diastolic blood pressure, heart rate, presence of diabetes, use of antihypertensive medications, number of cigarettes/day) at Year-0 and -25 examinations as independent predictors of echocardiographic outcomes at the Year-25 examination (LV end-diastolic volume [LVEDV]/height, LV end-systolic volume [LVESV]/height, LV mass [LVM]/height, and LVM/LVEDV ratio for LV structural indices; LV ejection fraction [LVEF], Ell, and Ecc for systolic indices; and early diastolic and atrial ratio, mitral annulus early peak velocity, ratio of mitral early peak velocity/mitral annulus early peak velocity; ratio, left atrial volume/height, longitudinal peak early diastolic strain rate, and circumferential peak early diastolic strain rate for diastolic indices). Compared with women, African American and white men had greater LV volume and LV mass (P