In Vivo Intravascular Optical Coherence Tomography (IVOCT) Structural and Blood Flow Imaging Based Mechanical Simulation Analysis of a Blood Vessel
In Vivo Intravascular Optical Coherence Tomography (IVOCT) Structural and Blood Flow Imaging Based Mechanical Simulation Analysis of a Blood Vessel
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DOI：
10.1007/s13239-022-00608-4
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发表时间：
2022-02
影响因子：
1.8
通讯作者：
Cuiru Sun;Hang Pan;Jun-dong Jia;Haofei Liu;Jinlong Chen
中科院分区：
文献类型：
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作者：
Cuiru Sun;Hang Pan;Jun-dong Jia;Haofei Liu;Jinlong Chen
前言基于生物医学成像的血管计算机建模为血管疾病的研究和诊断提供了重要的血液动力学和生物力学信息。然而，由于缺乏明确的生理血流曲线，模拟结果的准确性往往得不到保证。在活体多普勒血管内光学相干断层扫描(IVOCT)中，最近获得了血管特定横截面的血流速度分布。然而，由于导管的影响，IVOCT成像的速度分布不能直接用于模拟。方法提出了一种基于模拟和实验相结合的方法来确定活体颈动脉多普勒IVOCT成像的入口血流边界。采用图像处理和计算机辅助设计相结合的方法，从三维IVOCT结构图像中建立单管道颈动脉模型。结果利用高分辨率动脉模型和近生理血流剖面，进行了流固耦合应力分析和计算流体动力学。分析了在测量的入口流量和不同出口压力边界条件下，导管对管壁剪应力、血流动力学和颈动脉壁应力的影响。结论本研究为动脉数值模拟提供了一种获取入口流量边界的困难的解决方案。这为开发基于IVOCT的血管应力分析和成像方法用于血管疾病的研究和诊断铺平了道路。
IntroductionComputer modelling of blood vessels based on biomedical imaging provides important hemodynamic and biomechanical information for vascular disease studies and diagnosis. However due to lacking well-defined physiological blood flow profiles, the accuracy of the simulation results is often not guaranteed. Flow velocity profiles of a specific cross section of a blood vessel were obtained byin vivoDoppler intravascular optical coherence tomography (IVOCT) lately. However due to the influence of the catheter, the velocity profile imaged by IVOCT can’t be applied to simulation directly.MethodsA simulation-experiment combined method to determine the inlet flow boundary based onin vivoporcine carotid Doppler IVOCT imaging is proposed. A single conduit carotid model was created from the 3D IVOCT structural images using an image processing-computer aided design combined method.ResultsWith both high- resolution arterial model and near physiological blood flow profile, stress analysis by fluid-structure interaction and computational fluid dynamics were performed. The influence of the catheter to the wall shear stress, the hemodynamics and the stresses of the carotid wall under the measured inlet flow and various outlet pressure boundary conditions, are analyzed.ConclusionThis study provides a solution to the difficulty of getting inlet flow boundary for numerical simulation of arteries. It paves the way for developing IVOCT based vascular stress analysis and imaging methods for the studies and diagnosis of vascular diseases.