Noninvasive detection of macrophages using a nanoparticulate contrast agent for computed tomography
Noninvasive detection of macrophages using a nanoparticulate contrast agent for computed tomography
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DOI：
10.1038/nm1571
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发表时间：
2007-05-01
期刊：
影响因子：
82.9
通讯作者：
Fayad, Zahi A.
中科院分区：
文献类型：
--
作者：
Hyafil, Fabien;Cornily, Jean-Christophe;Fayad, Zahi A.
“高危”动脉粥样硬化斑块的纤维帽突然破裂可触发冠状动脉中闭塞性血栓的形成，引起急性冠状动脉综合征。高风险动脉粥样硬化斑块的特征在于其特定的细胞和生物含量（特别是高密度的巨噬细胞），而不是它们对血管腔的影响。早期识别高危斑块可能有助于预防缺血性事件。检测冠状动脉中的高风险动脉粥样硬化斑块的一个主要障碍是缺乏允许以高空间和时间分辨率识别动脉粥样硬化斑块组成的成像模式。在这里，我们表明，巨噬细胞在兔动脉粥样硬化斑块中可以检测到与临床X射线计算机断层扫描（CT）扫描仪后，静脉注射造影剂形成的碘化纳米粒子分散与表面活性剂。这种造影剂可能成为CT冠状动脉临床评价的重要辅助手段。
Sudden fibrous cap disruption of 'high-risk' atherosclerotic plaques can trigger the formation of an occlusive thrombus in coronary arteries, causing acute coronary syndromes. High-risk atherosclerotic plaques are characterized by their specific cellular and biological content (in particular, a high density of macrophages), rather than by their impact on the vessel lumen. Early identification of high-risk plaques may be useful for preventing ischemic events. One major hurdle in detecting high-risk atherosclerotic plaques in coronary arteries is the lack of an imaging modality that allows for the identification of atherosclerotic plaque composition with high spatial and temporal resolutions. Here we show that macrophages in atherosclerotic plaques of rabbits can be detected with a clinical X-ray computed tomography (CT) scanner after the intravenous injection of a contrast agent formed of iodinated nanoparticles dispersed with surfactant. This contrast agent may become an important adjunct to the clinical evaluation of coronary arteries with CT.