Reconnecting Eye to Brain
Reconnecting Eye to Brain
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DOI：
10.1523/jneurosci.1711-16.2016
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发表时间：
2016-10-19
影响因子：
5.3
通讯作者：
Mason, Carol A.
中科院分区：
文献类型：
--
作者：
Crair, Michael C.;Mason, Carol A.
虽然我们对视网膜神经节细胞的再生能力了解很多，但在创伤性损伤或疾病引起的变性后，我们恢复视觉功能的能力仍然存在很大的障碍。在这里，我们总结了目前对轴突再生中调节轴突引导和靶标参与的因素的理解，并回顾了神经再生领域的现状，重点关注视觉系统，并重点介绍了使用其他模型系统的研究，这些模型系统可以为视觉系统再生的分析提供信息。这一概述是由神经科学协会卫星会议“重新连接视觉系统中的神经元”推动的，该会议于2015年10月举行，由国家眼科研究所赞助，作为其“大胆目标倡议”的一部分，由Carol Mason（哥伦比亚大学）和Michael Crair（耶鲁大学）共同组织。会议参与者的集体智慧指出了我们在促进视觉系统功能恢复方面的重要知识差距和进展障碍。因此，本文总结了我们对视觉系统再生的现有认识，并为该领域的未来发展提供了蓝图。
Although much is known about the regenerative capacity of retinal ganglion cells, very significant barriers remain in our ability to restore visual function following traumatic injury or disease-induced degeneration. Here we summarize our current understanding of the factors regulating axon guidance and target engagement in regenerating axons, and review the state of the field of neural regeneration, focusing on the visual system and highlighting studies using other model systems that can inform analysis of visual system regeneration. This overview is motivated by a Society for Neuroscience Satellite meeting, "Reconnecting Neurons in the Visual System," held in October 2015 sponsored by the National Eye Institute as part of their " Audacious Goals Initiative" and co-organized by Carol Mason (Columbia University) and Michael Crair (Yale University). The collective wisdom of the conference participants pointed to important gaps in our knowledge and barriers to progress in promoting the restoration of visual system function. This article is thus a summary of our existing understanding of visual system regeneration and provides a blueprint for future progress in the field.